Polyphasic

Question 1

Drug can only show activity in

Answer 1

molecular state

Question 2

What’s a phase?

Answer 2

Part of a system which is chemically & physically UNIFORM throughout and is separated from other portions of the system by bounding surfaces

Question 3

How many phases does gas have?

Answer 3

one

Question 4

How can liquids have different phases?

Answer 4

By have immiscilbe liquids ex. oil and water is 2 phases, but salt and water is one

Question 5

Phase theory helps what?

Answer 5

Understanding the conversion of solid state to liquid state

Question 6

Why does vapor pressure exsist in liquids?

Answer 6

Because of the uneven distribution of kinetic energy at the interface. Molecules at surface of liquid will vaporize and become gas. Some molecules will return back to liquid by condensation.

Question 7

What two factors does transition from gas liquid depend on?

Answer 7

Temperature and pressure

Question 8

What does temperature affect?

Answer 8

Kinetic energy

Question 9

What does pressure affect?

Answer 9

Distance between molecules

Question 10

Critical temp?

Answer 10

Temp above which liquid no longer exist irrespective of pressure. Gas can’t be liquified no more, no matter how much presure

Question 11

Critical pressure?

Answer 11

Pressure required to liquefy a gas. Turn gas into liquid at its critical temperature. Highest vapor pressure a liquid can have.

Question 12

Vapor pressure?

Answer 12

At some temp for a specific molecule, the pressure exerted by vapor. If something has low equilibrium vapor pressure that means the liquid is harder to vaporize into gas. Maybe it’s a heavier molecule or has stronger intermolecular forces that prevent it from becoming gas.

Question 13

Phase rule equation for one component system?

Answer 13

F= C-P+2
F is degrees of freedom
C is # of components
P is # of phases

Question 14

Ice and water F is?

Answer 14

F=0

Question 15

Water F is?

Answer 15

F=1

Question 16

Water vapor F is? And name the parameters that need to be used to define the state.

Answer 16

F=2, the 2 systems that need to be used to define water vapor is temperature and pressure.

Question 17

What the hell is sublimation?

Answer 17

Solid to gas

Question 18

Vapor pressure curve is from what state to what state? And how many phases exist on that line?

Answer 18

Liquid to gas. 2 phases, liquid and gas.

Question 19

Melting point curve is from what state to what state?

Answer 19

Solid to liquid

Question 20

What is the sublimation curve? How many parameters do we need to define it?

Answer 20

Solid to gas state. One parameter, it can be either pressure or temp.

Question 21

How many phases exist on the triple point? How many parameters needed to define?

Answer 21

All 3 phases. No parameters needed.

Question 22

Phase rule equation for one component system?

Answer 22

F=C-P+1

Question 23

Eutectic point is?

Answer 23

Point where the temp will turn solid straight to liquid for both components (ex. thymol and salol) Lowest melting point. Lower than each of the mps for the each component.

Question 24

Eutectic system can be used to prepare solid disperisions and solutions. What does it do to drug solubility?
Particle size?
Drug dissolution rate?
Agglomeration of particles?
Wettability of material?

Answer 24

What does it do to drug solubility? increase
Particle size? reduce
Drug dissolution rate? increase
Agglomeration of particles? reduce
Wettability of material? increase

Question 25

3 component system. How many components in outer line? Inner line?

Answer 25

2, 3