Particles, Particle Size Issues and Solid Dosage Forms

Question 1

Particle generally smaller than _____ mm?

Answer 1

10mm

Question 2

Larger the sieve number, the _______ the size of opening to let powders through?

Answer 2

Smaller

Question 3

2 reasons why it’s better for suspension to have smaller particles?

Answer 3

1. Less problem w aggregation

2. Slower settling rates (larger particles will fall faster)

Question 4

Definition of an emulsion?

Answer 4

Liquid particle suspended in a liquid medium, either o/w or w/o with an emulsifier

Question 5

Name some emulsifiers

Answer 5

Natural gum like acacia, non-ionic surfactant, ionic surfactant

Question 6

Particle size for emultions

Answer 6

40 microns or less

Question 7

particle size for suspensions, fine and coarse

Answer 7

Fine: 10-50 microns
Coarse: >50 microns

Question 8

1 reason why solid or liquid drugs in cream/ointments must be as small as possible?

Answer 8

Prevent chemical burn on skin

Question 9

1 reason why aerosol drug particles must be small?

Answer 9

To reach deep recesses of the lung

Question 10

1 reason why parenteral drug must be small?

Answer 10

Smaller than 5 microns so they don’t block capillary blood flow

Question 11

What is pyrogenic in body and what are the 2 large categories fo pyrogenic particles?

Answer 11

Causes fever.

1. Lint fibers, glass particles
2. Endotoxins released by bacteria (ALL ENDOTOXINS ARE PYROGENIC)

Question 12

2 tests for particulates in parenteral solutions.

Answer 12

1. Rabbit test

2. L.A.L test

Question 13

What can the L.A.L. test detect in parenteral solutions?

Answer 13

Endotoxins only

Question 14

What size filtering device can sterilize drug? And name 3 devices that can do that

Answer 14

0. 22 microns
1. end-of-line devices
2. devices for syringe administration
3. devices to prepare LVPs

Question 15

T/F Spherical shaped particles are easier to mix than needle/cubic shaped ones

Answer 15

T

Question 16

Larger particles tend to:
Rise to surface?
Sink to bottom?

Answer 16

Rise to surface wehen shaken w smaller particles

Question 17

Adhering/repelling properties of powders. What do add?

Answer 17

Add inert material like starch or lactose to help with blending in the powder

Question 18

What 2 things can milling do?

Answer 18

Increase efficiency of drug absorption and lower the dose admin

Question 19

Oil filled capsules should be ________ and _________.

Answer 19

wet seals; double capsuled

Question 20

Capsule size. Is 000 bigger or smaller than 5?

Answer 20

000 is largest, then 00, 0, 1, 2, 3…