Polypharmacy Flashcards
1
Q
Polypharmacy
A
> 5 or more medication on the patient’s medical register (temp, permanent)
2
Q
Polypharmacy causes
A
- Multiple co-morbidities
- Blindly following guidelines
- Lack of follow up / review
- Poor comm
- Undetected adherance
3
Q
Polypharmacy absorption changes
A
- Increase GI pH
- Reduced GI blood flow
4
Q
pharmakinetics
Polypharmacy distribution
A
- can increase with increased proportion of fat
- Reduced serum albumin
- cachetic = narrow theraputic index of drugs e.g. digioxin
5
Q
pharmakinetics
Hepatic mechanism in polypharmacy
A
- Delayed liver metabolism
- can stay in the body for longer
6
Q
pharmakinetics
Renal excretion in polypharmacy
A
Drugs / metalites mostly excreted through the kidney
7
Q
Pharmacodynamics 4 targets for drug interactions
A
Enzymes - induce, inhibit, activate
Membranes carriers - enhance, inhibit or release
Ion channels - block/open
Receptors - agonist / antagonist
8
Q
What Anticholinergic Burden - ACB score may increase dysfunction
A
ACB score 3 or more may increase the risk of cog. impairment, func. impairment, falls and mortality in older adults
9
Q
STOPP/START tool
A
