Polyoma viruses

Question 1

Characteristic of polyoma?

Answer 1

Circular ds DNA [5-8] kbp

Non-enveloped icosahedral capsid

Question 2

Can polyoma lead to tumor formation? If so, in what type of cells?

Answer 2

Yes

Non-permissive cells

Question 3

What polyoma antigens are required to take a primary non-permissive cell to an immortal cell? Immortal to transformed?

Answer 3

Large T-antigen & Small T-antigen

Middle T-antigen & Small T-antigen

Question 4

Known human polyoma viruses?

Answer 4

BK and JC

Question 5

Can polyoma cause cancer in humans?

Answer 5

Nope

Question 6

Is most of the adult population seropositive for polyoma virus?

Answer 6

Yes

both BK and JC

Question 7

Polyoma is transferred through?

Answer 7

Respiratory inhalation

Question 8

Where does polyoma become latent in an immunocompetent host?

Answer 8

Kidneys

Question 9

Where does polyoma initial multiply?

Answer 9

Respiratory tract

Question 10

Which patients are polyoma typically seen in?

Answer 10

Immunodeficient - Transplant pts and AID pts

Question 11

BK polyoma virus can cause what upon reactivation?

Answer 11

Hemorrhagic cystitis

Question 12

What does JC polyoma virus cause upon reactivation?

Answer 12

Progressive multifocal leukoencephalopathy

Question 13

Describe progressive multifocal leukoencephalopathy (PML)?

Answer 13

Demyelinating
Mid to late life
Often death within 3-6 months
Reactivated JC virus infects and lyses oligodendrocytes