Polymer characterisation

Question 1

what are some examples of polymer characterisation?

Answer 1

1.MW
2. thermal properties

Question 2

What information is useful about MW

Answer 2

number-average of MW (Mn)
weight-average MW (Mw)
polydispersity index (PI) - width of MW distribution

Question 3

how can thermal properties of polymers be assessed?

Answer 3

thru DSC - differential scanning calorimetry using a thermogram

Question 4

depict a thermograms characteristics

Question 5

how are polymer-drug conjugates select a linker?

Answer 5

ideally should prevent release in the blood and enable specific drug release

non-biodegradable linkers/environmental-sensitive linkers
sensitive to intracellular enzymatic degradation

Question 6

what are some examples of intracellular enzymatic degradation

Answer 6

Gly-Phe-Leu-Gly
Ala–Leu-Ala-Leu

break at specific amino acid chain sequence

Question 7

what are pH sensitive linkers?

Answer 7

esters and hydraxzones

Question 8

what happens if there’s a low ph environment outside of the linker?

Answer 8

can cause degradation

Question 9

what are the functions/characteristics of dendrimers?

Answer 9

multiple surface functionalities
- active targeting
- drug binding
- labelling

spherical shape
small size (<10nm)
difficult to synthesis