Polyketides

Question 1

What are the major groups of fungal SM’s?

Answer 1

Polyketides (PKS)
* Nonribosomal peptides (NRPs)
* Terpenes
* Alkaloids

Question 2

Polyketide synthesis is related to what synthesis?

Answer 2

Eukaryotic fatty acid synthases

Question 3

Polyketide SM (Aflatoxins) causes?

Answer 3

Aflatoxicosis resulting from inhalation or ingesting high levels of aflatoxin contaminated food

Question 4

Aflatoxin name comes from?

Answer 4

Aspergillus flavus

Question 5

Four types of aflatoxin?

Answer 5

B1, B2, G1 and G2

Question 6

How are the four types of aflatoxin distinguished?

Answer 6

Based on their blue or green fluorescence under ultraviolet light and their relative chromatographic mobility during thin layer chromatography with silica gel

Question 7

Polyketide SM (Lovastatin) is a what type of agent?

Answer 7

Cholesterol and triglyceride lowering agent

Question 8

Lovastatin is isolated from?

Answer 8

Aspergillus terreus