Polyclona Ab therapy Flashcards
What is the target of Abatercept?
Targets B7 (does the job of CTLA-4) recombinant EX portion of CTLA-4 and Ig
What is the target of etanercept?
TNF- recombinant fusion of TNFR and Ig.
What is the target of Natalizumab?
a4B1/7
What infections are of concerned being transfused with IVIg?
HIV, HCV, HBV, HAV and parvovirus (B19)
Examples of biologically active soluble components in IVIg?
soluble HLA II CD4 CD8 and TGF-B
What two ways can IVIg be used in therapy?
For immunodeficiencies, or as an immunomodulator.
Why might IVIg help in ITP?
In this disease, blood doesn’t clot properly.
IVIg will prevent Ab on platelets from binding Fc receptors on macrophages and gobbling them up.
In what disease can IVig decrease the risk of cardiovascular disease (better than aspirin)?
In Kawasaki disease (patchy peeling rash, vasculitis and inflammation of coronary arteries).
What neuropathies can IVIg be used in?
Used in GBS and CIDP peripheral neuropathies and also in myasthenia gravis and AQP4 and MOG diseases.
and autoimmune encephalitis.
What dermatological disease is IVIg effective in?
pemphigous volgaris, but rituximab works better.
What is the receptor rseponsible for Ig recycling and inhibitory signals?
FcyRIIB inhibitory
and FcRn recycling one.
two ways IVIg may have benefit in autoimmune diseases?
By upregulating FcyRIIB expression
and preventing autoantibodies from interacting with FcRn to promote their catabolism.
