Polar amino acid Flashcards
The abbreviation of serine?
Ser/S
The R group of S contain?
The R group of Serine contain polar hydroxyl group
Can serine be ionizable?
No,it can’t lose (H+)(not titrable)
The abbreviation of Threonine?
Thr/T
The R group of Thr contain?
Polar Hydroxyl group
In S and T in which carbon of R group the hydroxyl group attach?
In serin and Threonine the (oH)attach on B_carbon
How many assymetric carbon in T?
2 assymetric carbon(الفا وبيتا)
What is the polar uncharged amino acid that has two chiral (assymetric)carbon?
Threonine
The only two amino acids that contain two assymetric carbon(الفا وبيتا)?
Isoleucine(Ile/I),Threonine(Thr/T)
The abbreviation of Tyrosine?***
Tyr/y
The polar amino acid that derived from phe(phenylalanine)?
Tyr/y🙃(Tyrosine).
The R group in Y contain?
Phenol group (the name of amino acid:Tyrosine).
The polar aromatic amino acid?
Y/Tyr🙃
The amino acids that contain aromatic side chain?
Phenylalanine(Phe/F), Tryptophan(Trp/W),Tyrosine(Tyr/Y)
Is Tyr/Y titrable?
Yes,(at pH=7,OH protonated and Neutral)and(at PH bigger than 10.07, O- deprotonated and negative).
The abbreviation of Cysteine?
Cys/C
R in Cys contain?
Sulfohydryl(Thiol)group
R in Cys contain?
Sulfohydryl(Thiol)group
The polar amino acid that contain sulfer?
Cys/C(Cysteine)
The amino acids that contain sulfer?
Methionine(Met/M), Cysteine(Cys/C)
Is sulfer reactive in Cys?
Yes, cause it’s terminal (but remember sulfer in Met not reactive cause it’s within the skeleton)🤝
Is cycteine titrable?
Yes,(at PH=7, SH protonated and Neutral)and(at PH higher than 8.18, S- deprotonated and negative.
The abbreviation of Asparagine?***
Asn/N
Side chain in (Asn/N)?
In Asparagine the R group contain (polar amide group at B_carbon)(CONH2)
Is N titrable?
No, Asn(Asparagine) not titrable
The abbreviation of Glutamine?***
Gln/Q
R group in (Gln/Q)?
Contain polar amide(CONH2)
Q titrable?
No,Glutamine not titrable
Which side chain is longest in Asn or Gln?
In Glutamine side chain is longer(and remember in Asparagine amide attach on( B_carbon ),but in (Q) it attach on( y_carbon)
When two Cystein undergo oxidation will form?and what’s the name of bond?
Cystine, covalent bond (disulfide bond)(this bond stabilize the structure of the protein)(and remember Cystine not amino acid).
What are the acidic amino acids?
Aspartic acid and Glutamic acid(they have acidic R group which is negatively charged at PH=7)
The abbreviation od Aspartic acid?***
Asp/D
The abbreviation of Glutamic acid is?***
Glu/E
Asp and Glu have side chain contain?
Polar carboxyl group(but in Aspartic acid (COOH) attach at B_carbon)and in Glutamic acid attach at(y_carbon), so R group in( E) is longer than( D).
Aspartate is?
Deprotonated form of Aspartic acid and is precursor for Asparagine.🥲
Glutamate is?
Deprotonated form of Glutamic acid and precursor for Glutamine.🥲
The basic amino acids are?
Lysine/Histidine/Arginine
The abbreviation of Lysine?***
Lys/k
R group in Lysine(Lys/k) contain?
Amine(NH3+)(the name of side chain:Butyl_ammonium)
The abbreviation of Histidine?
His/H
The R group in (His) contain?
Imidazol ring
The basic amino group that has pka=6 close to physiologic PH and work as abuffer inside the body?
Histidine(basic structure with asidic pka).
What is the factor that makes protein work as abuffer?
If it has big amount of histidine(high content) (just like hemoglobin).
What is the abbreviation of Arginine?***
Arg/R
R group in Arg contain?
Guanidino group
The charge of basic amino acid at PH=7 will be?
Positive charge🙃
Are acidic and basic amino acid ionizable?
Yes
