PNS1 Flashcards

1
Q

How many pairs of cranial nerves are there?

A

12

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2
Q

Bundles of axons in the CNS are referred to as “tracts.” What are they called in the PNS?

A

Nerves

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3
Q

Collections of nerve cell bodies in the CNS are called Nuclei. What are they called in the PNS?

A

Ganglion

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4
Q

What does each of the following stand for? What is the purpose of each?

  1. GSA
  2. GVA
  3. GSE
  4. GVE
A
  1. GSA = General Somatic Afferent nerves, which cary signals from joints, skin, and skeletal muscle to CNS
  2. GVA = General Viserosensory Afferent nerves, which carry signals from viscera and vessels to CNS
  3. GSE = General Somatomotor Efferent nerves, which carry signals from CNS to skeletomuscle
  4. GVE = General Viscerosensroy Efferent nerves, which carry signals from CNS to glands, smooth muscle, & cardiac muscle
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5
Q

At what vertebral level does the spinal cord terminate? What does it terminate into?

A

The cord tapers caudally at the L1-L2 intervertebral level and terminates into the CONUS MEDULLARIS.

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6
Q

Arising from each segment of the spinal cord are the (1) GSA & (2) GSE fibers which, respectively, supply

  1. a specific area of body wall called the?
  2. and a specific muscle mass called the?
A
  1. The GSA supply the specific area of body wall called the DERMATOME
  2. The GSE supplies the specific muscle mass called the MYOTOME
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7
Q

What are the two main differences b/t ROOTS and RAMI?

A

Roots: 1. Lie within the vertebral column
2. Afferent and Efferent Fibers in roots = segregated
Rami: 1. Outside of vertebral column
2. Contain a mixture of somatic afferent and efferent fibers.

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8
Q

Which is larger the Ventral primary ramus or the Dorsal primary ramus? What is the muscle group that each supplies?

A
  • The Ventral (anterior) Ramus is larger and supplies the HYPAXIAL Muscles. Note: Also supplies anterolateral body wall and extremities
  • The Dorsal (posterior) Ramus is smaller and supplies the EPAXIAL Muscles. Note: Also supplies skin of the posterior scalp, facet joints and the posterior ligaments of the spine
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9
Q

In the somatic system, how many neurons are there between the CNS and either the skeletal muscles innervated by GSE fibers or Sensory recptors innervated by GSA fibers?

A

ONE

-There is Only 1 neuron b/t the CNS and the PNS endpoint

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10
Q

Cutaneous receptors are responsible for transducing action potentials from what part of the body to the CNS? What are the receptors that are responsible for creates the action potential that the cutaneous receptors receive? What is unique about these receptors?

A

Cutaneous nerves carry information from EXTEROCEPTORS, in the SKIN, to the CNS.
-EACH exteroceptor is sensitive to a PARTICULAR form of physical energy or STIMULUS.

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11
Q

What stimuli do each of the following exteroceptors respond to?

  1. Mechanoreceptors?
  2. Thermoreceptors?
  3. Nociceptors?
A
  1. Deformation or displacement of skin
  2. Changes in temperature
  3. Responds to stimuli that damage tissue
    (–>PAIN)
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12
Q

The Cutaneous Receptors are continuous with peripheral processes of what?
-The soma of the above peripheral processes are located in the Dorsal or Ventral root ganglia?

A

(Pseudounipolar) Sensory Neurons;

-These Sensory Neurons have soma that are located in the DORSAL Root (Spinal) Ganglia.

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13
Q

What is a dorsal root (spinal) GANGLION?

A

Each Dorsal Root GANGLION is a collection of Pseudounipolar Sensory Neurons located on the dorsal root in an intervertebral foramen, just proximal to the mixed spinal nerve.

  • Note: In the Dorsal (posterior) Root there are only Afferent fibers b/c the dorsal root receives information from the periphery and passes it onto the Dorsal Horn in the CNS
  • Ganglion = collection of functionally related nerve cell bodies that are located OUTSIDE of the CNS
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14
Q

Once in the CNS the inputs from the Dorsal Root Ganglia are segregated how?

A

by Modality (or function).

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15
Q

What is Referred VISCERAL Pain?

A

It is pain felt far away from the visceral source caused by communication between Visceral Afferent nerves (viscera & vessels) and Somatic Afferent nerves (joints, skin & skeletal muscle).
-Ex. Pain from a heart attack is carried by Visceral Afferents from the source (the heart) but along its journey back to the CNS the Visceral Afferent comes in close contact with (and communicates with) a Somatic Afferent from the Left arm causing this Somatic Afferent also to signal pain to the CNS. This is why pain is felt in the left arm during a heart attack even though there is nothing wrong with the left arm.

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16
Q

The spinal nerves contributing to the brachial and lumbosacral plexuses innervate what?

A

Brachial Plexus: Innervates upper limbs

Lumbosacral plexus: Innervates lower limbs

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17
Q

Individual peripheral nerve fibers consist of what 3 components?

A
  1. Axons
  2. Neurolemma (myelinated or unmyelinated)
  3. ENDONEURIAL connective tissue (Endonerium)
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18
Q

Individual peripheral nerve fibers are bundled into FASCICLES surrounded by what dense connective tissue?

A

Perinerium

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19
Q

In addition to peripheral nerve fascicles what 3 other components are ensheathed by the outermost, thick EPINEURIUM to form each PERIPHERAL NERVE?

A

In addition to the fascicles peripheral nerves consist of

  1. Vasa Nervosum (blood vessels)
  2. Fatty tissue (cushioning)
  3. Lymphatics (Fight infections)
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20
Q

What caudal portion of the brain stem does the spinal cord descend from and through what foramina does it exit the skull?

A

The spinal cord descends from the MEDULLA OBLONGATA and exits the skull via FORAMEN MAGNUM.

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21
Q

The cord descends through the VERTEBRAL CANAL enclosed within what until the S2 level?

A

As the spinal cord descends through the Vertebral canal it is surrounded by a closed DURAL (Thecal) sac, which consists of the 3 meningeal layers (dura, arachnoid & pia), and descends to the S2 level of the spine.

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22
Q

T or F: Each pair of spinal nerves is derived by the convergence of fibers from both the dorsal and ventral aspects of an individual segment of the cord?
What fiber type is associated with the dorsal and the ventral horns respectively?

A

True.

  • The Dorsal Horn receives Somatic Afferent fibers from the DORSAL (posterior) ROOT
  • The Ventral Horn gives rise to Somatic Efferent fibers in the VENTRAL (anterior) ROOT
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23
Q

Somatomotor fibers (GSE) stimulate voluntary and what other type of contraction of skeletal muscle?

A

Somatomotor (GSE) fibers stimulate voluntary and REFLEX contraction of skeletal muscle

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24
Q

What are the two main types of information somatosensory fibers transmit to the CNS?

A
  1. Touch, pain, pressure & temp from the body wall
  2. Proprioception from muscles, tendons & joints. Proprioception gives the ability to know where a finger or body part is without visualizing it.
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25
Q

The mixed ventral and dorsal rami converge briefly to form what SMALL, mixed spinal nerve that is susceptible to spinal nerve injuries and branches into the segregated dorsal and ventral roots inside the spinal column?

A

The INTERVERTEBRAL (IV) FORAMEN is a small, mixed spinal nerve b/t rami and roots of the PNS.

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26
Q

What is a DERMATOME?

How does the fact that dermatomes overlap prevent perceptual anesthesia?

A
  1. A dermatome is the Specific Area of SKIN innervated by Somatic Afferents arising from a single pair of spinal nerves from a specific spinal cord segment.
  2. Dermatomes overlap so that the LOSS of a single spinal nerve or dorsal root will not cause ANESTHESIA
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27
Q

Exteroceptive and PROPRIOCEPTIVE inputs enter the spinal cord via the central processes of the neurons in the Dorsal Root Ganglia.
-Where are PROPRIOCEPTORS located?

A

Proprioceptors are located in Muscles, Tendons & Joints.

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28
Q

Contraction of skeletal muscle is a direct result of stimulus by what?

  • Where are they located?
  • What are the majority of these neurons and what does there stimulation cause?
A

LOWER MOTOR NEURONS cause contraction of skeletal muscle and are located in either the Brainstem or Spinal Cord.

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29
Q

Most lower motor neurons are a particular type that innervate muscle that allow for skeletal movement. -What is the particular motor neuron?
-What is the particular muscle fiber whose contraction generates tension allowing for skeletal movement?

A

Most of these Lower Motor Neurons are
ALPHA MOTOR NEURONS innervating EXTRAFUSAL MUSCLE FIBERS whose contraction generates Tension allowing for skeletal movement.

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30
Q

The VENTRAL ROOT conveys Axons of Lower Motor Neurons to the mixed Spinal Nerves. Where are the lower motor neuron CELL BODIES located?

A

The Cell Bodies are located in the VENTRAL HORNS of the Spinal Gray matter.
-This is really a very simple question you just have to understand the terminology. Cell bodies = Nerve Cell nuclei in the CNS. And Ventral Root (in PNS) corresponds to Ventral Horn (in CNS).

31
Q

T or F: Lower Motor Neurons located in the brain stem give rise to axons found in all 12 pairs of Cranial Nerves?

A

False. Lower motor neurons located in the brain stem give rise to axons found in nine of twelve pairs of cranial nerves.

32
Q

Each muscle fiber is innervated by how many neurons?

A

Each muscle fiber is innervated by a single alpha motor neuron.
Note: Each motor neuron innervates multiple muscle fibers (added together = motor unit).

33
Q

The terminal ends of Lower Motor Neurons lose their myelin sheaths, branch significantly and terminate where?

A

Lower motor neurons terminate near the middle of muscle fibers at the NEUROMUSCULAR JUNCTION.
Note: In somatics there are no neuron-neuron synapses in the PNS. Single Lower Motor Neurons travel from CNS directly to target.

34
Q
  • What is the cause of IRRITATIVE TRAUMA to Peripheral Somatic Nerves?
  • What is the result of irritative trauma? How does it differ in Sensory vs. Motor Fibers?
A

Irritative trauma is caused by Acute or Chronic Mechanical Trauma or Inflammation (i.e. compression, constriction, or stretching).

  • In Sensory (Afferent) fibers Irritative trauma may cause Pain or PARASTHESIA (=altered sensation = pins and needles or numbness)
  • In Motor (Efferent) fibers Spasms or Twitching can result.
35
Q

What is PARASTHESIA? Usual cause?

A

Parasthesia is altered sensation such as pins and needles or numbness. Parasthesia is often caused by Irritative trauma to sensory peripheral nerves (somatic Afferents).

36
Q

DESTRUCTIVE injuries to Peripheral nerves may result from Trauma or Neuropathy. What are the usual motor and sensory symptoms?

A

Motor Symptoms = PARALYSIS or PARESIS (=weakness)

Sensory Symptoms = Anesthesia (=lacking ALL sensation) or HYPESTHESIA (=Diminished sensation)

37
Q

What is the Visceral nervous system responsible for innervating?

A

Viscera (internal organs)

38
Q

What part of the visceral nervous system makes up the AUTONOMIC NERVOUS SYSTEM (ANS)?
-While the ANS is part of the PNS what is a caveat having to do with the overall control of the ANS?

A

The GVE fibers or MOTOR Component of the Visceral nervous system makes up the ANS.
-While the ANS is generally considered part of the PNS the Visceral Efferent Neurons of the ANS are under the control of higher CNS Centers.

39
Q

What are the two divisions of the ANS?

A

The Sympathetic and Parasympathetic

40
Q

The GVE components play a large role throughout the body controlling the ANS and innervating smooth and cardiac muscle as well as regulating glands. But what 2 roles do the SENSORY (GVA) Component of the Visceral system play?

A
  1. Conveys normally vague & poorly localized ORGANIC Pain as well as VISCERAL Sensations such as hunger, satiety, nausea, anxiety, & stress.
  2. GVA also conveys information related to Visceral REFLEXES such as information gathered from Mechanoreceptors, Baroreceptors & Chemoreceptors.
41
Q

Briefly compare Sympathetic and Parasympathetic systems.

-What is something that they have in common?

A
  • Sympathetic: Arousal, fight or flight, Catabolic, Widely Distributed.
  • Parasympathetic: Conserves/restores energy, Anabolic, Restricted Distribution.
  • BOTH Divisions employ TWO NEURONS in SERIES to provide visceral motor innervation to target tissues.
42
Q

What does the “Two-Neuron” Rule apply to?

A

The “Two-Neuron” Rule applies to the ANS because in both the symp and parasymp nervous systems both have Pre- and Postganglionic Axons/neurons that together carry the signal from the CNS to the PNS.

43
Q

What is the difference in the length of the Preganglionic axons of the sympathetic and parasympathetic nervous systems?

A
Sympathetic = SHORT. Synapse is located NEAR the SPINAL CORD.
Parasympathetic = LONG. Synapse is located NEAR the TARGET ORGAN.
44
Q

What effects do the sympathetic and parasympathetic nervous systems have on the heart?

A

Symp: Increase heart rate
Para: Decrease heart rate

45
Q

Why is the parasympathetic division of the ANS described as a CRANIOSACRAL SYSTEM?

A

Bc preganglionic neuron cell bodies (nuclei in CNS) are located in either of two places

  1. Brain stem or nuclei (CRANIAL)
  2. The VENTRAL HORNS fo the S2-S4 Spinal Cord Segments (SACRAL)
46
Q

Specifically, what are 4 cranial nerves that carry preganglionic parasympathetic axons out of the brainstem?

A
  1. CN III - Occulomotor Nerve
  2. CN VII - Facial Nerve
  3. CN IX - Glossopharyngeal Nerve
  4. CN X - Vagus Nerve
47
Q

Parasympathetic, Preganglionic axons leaving the spinal cord in the ventral roots of the S2-S4 spinal nerves form what?
-What do these nerves innervate?

A

PELVIC SPLANCHNIC NERVES provide parasympathetic innervation to lower GI, Pelvic & Perineal Organs.

48
Q

CN X - the Vagus Nerve provides parasympathetic innervation to what 3 (GENERAL) sites?

A
  1. Cervical (neck)
  2. Thoracic (heart & lungs)
  3. Upper GI Viscera (stomach/intestine)
49
Q

Visceral Afferent fibers convey sensations of visceral pain and physiological sensations. The physiological sensations arise from what two receptors? Describe each.

A
  1. Mechanoreceptors: Respond to distension in the walls of the GI tract, respiratory structures, urinary bladder & Baroreceptors in blood vessels.
  2. Chemoreceptors: Respond to changes in partial pressure of O2 & CO2 in the blood stream, blood pH & hydrogen ion concentration in the stomach.
50
Q

In the Sympathetic Division the Preganglionic Cell Bodies are located in the Intermediolateral Horns of what segments of what spinal segments?

A

The intermediolateral horns of the T1 to L2 spinal segments

51
Q

After leaving the intermediolateral horns the preganglionic sympathetic axons leave the spinal cord in what? And then exit the vertebral canal in the what?

A

The sympathetic axons leave the spinal cord (CNS) in the VENTRAL Roots of the T1-L2 Spinal Nerves and then exit the vertebral canal on the T1-L2 Spinal Nerves.

52
Q

The Sympathetic Division of the ANS is referred to as what?

A

The THORACOLUMBAR SYSTEM

-Bc arises from T1-L2 spinal cord segments

53
Q

Preganglionic sympathetic axons, after leaving the cord via the T1-L2 spinal nerves, head for what bilateral chains of interconnected ganglia? Hint: Located in the Paravertebral Gutters along each side of the spine.

A

THE SYMPATHETIC TRUNKS

54
Q

How far do the sympathetic trunks extend superiorly and inferiorly?

A

The Sympathetic Trunks extend from the base of the skull to the Coccyx where the left and right branches come together, terminating at the Ganglion Impar (the inferior most point where the branches meet)

55
Q

The Ganglia in the Sympathetic Trunks (Chains) are called what?

A

PARAVERTEBRAL GANGLIA bc of their close relationship to the spinal cord and vertebra

56
Q

What tiny nerve bundles are responsible for bringing the Preganglionic Sympathetics to the Chain?

A

WHITE RAMI COMMUNICATES (or White Communicating Rami). Note: White b/c they are Myelinated

57
Q

What are the FOUR potential fates of preganglionic sympathetics that are be brought to the Sympathetic Chains via the White Rami?

A
  1. Enter the Chain & Synapse at the nearest Ganglion
  2. Ascend the Chain & Synapse at a more Superior ganglion
  3. Descend & Synapse at an Inferior Ganglion
    - Note: 2 & 3 are necessary b/c the Chain is longer than the distance from T1-L2.
  4. Some axons will pass through the chain without synapsing & must find synapses elsewhere.
58
Q

If synapse does occur in the Chain, what happens if Gray Rami Communicantes Shepard the postganglionic sympathetics to their next destination?

A
  1. Most POSTSYNAPTIC SYMPATHETICS rejoin spinal nerves for distribution to the BODY WALL.
    - GRAY (unmyelinated) RAMI COMMUNICANTES will convey these postsynaptic sympathetic fibers back to the Spinal Nerves.
59
Q

How does the distribution of white and gray Rami differ?

A

White Rami are only found in the T1-L2 spinal nerves while Gray Rami are found in ALL spinal nerves.

60
Q

What 3 body wall structures receive sympathetic innervation? Describe the affect on each briefly.

A
  1. Sweat Glands - increases sweat
  2. Arrectores Pilli - Smooth muscle of the hair cell results in Piloerection
  3. Vascular Smooth Muscle - Induces VasoConstriction of Peripheral Vessels and VasoDilation of Vessels to Skeletal Muscle
61
Q

Generally, how do you “turn off” these Body Wall Structures that are “turned on” by a Sympathetic Stimulus? Why is this an important point?

A

You merely REMOVE THE STIMULUS.
-This is important b/c it demonstrates that the body wall structures do NOT have dual-innervation. Body Wall structures are ONLY innervated by the sympathetic system. This is b/c the Parasympathetic system is limited in its physical distribution.

62
Q

Again, if synapse occurs in the neck region, many postganglionic axons arising from CERVICAL GANGLIA will leave the Sympathetic Chains and form what?

A

PERIARTERIAL PLEXUS
-Postganglionic axons that leave Cervical Ganglia form Periarterial Plexus on the CAROTID ARTERIES and their branches to reach Cranial and Cervical Viscera.

63
Q

Interruption/impingement of Cervical Sympathetic Fiber Pathways (i.e. Periarterial Plexus) results in HORNER’S SYNDROME. Horner’s Syndrome is characterized by a triad of symptoms, what are they?

A
  1. PTOSIS = Droopy eyelid
  2. MIOSIS = Fixed, constricted pupil
  3. ANHIDROSIS = Absence of sweating
64
Q

Some postganglionic fibers arising in Cervical and Upper thoracic Ganglia as DIRECT VISCERAL BRANCHES and go where?

A

To Cervical and Thoracic Viscera.

Mainly to the HEART.

65
Q

Ischemia may produce what?

A

Ischemia (= a lack of oxygen to the myocardium) may produce REFERRED CARDIAC PAIN.
-Contact, cross talk, communication b/t the Visceral Afferent (original pain caused by Ischemia) with the SOMATIC AFFERENT within the DORSAL ROOT results in Referred Pain.

66
Q

Bundles of Preganglionic Sympathetic axons that exit the chain without synapsing are called what?

A

SPLANCHNIC NERVES

Note: Also known as VISCERAL NERVES

67
Q

SPLANCHNIC NERVES synapse where? Do what?

A

Splanchnic nerves synapse on either COLLATERAL or PREVERTEBRAL Ganglia.
Postsynaptic Splanchnic nerves regulate Neuroeffector junctions on smooth muscle, cardiac muscle, secretory glands.

68
Q

Thoracic Splanchnic Nerves contain Preganglionic Sympathetic fibers destined for the Abdomen. Thoracic Splanchnic Nerves pierce the Diaphragm and seek synapse on neurons where? A limited number of Thoracic Splanchnics travel further to where?

A
  1. Most Thoracic Splanchnic Nerves, once they’ve pierced the diaphragm and entered the abdomen synapse on neurons in PREAORTIC (PREVERTEBRAL) GANGLIA.
  2. Some pass through the Preaortic Ganglia and synapse in the ADRENAL MEDULLA.
69
Q

How do postganglionic sympathetic fibers arising from Prevertebral (Preaortic) Ganglia reach their Visceral targets?

A

Postganglionic sympathetics arising from prevertebral ganglia form a PERIARTERIAL PLEXUS along arteries arising from the ABDOMINAL AORTA.

70
Q

Where are the two places we see PERIARTERIAL PLEXUSES formed?

A
  1. Along the Carotid Artery and its branches in the neck. Formed by postganglionic sympathetics arising from the Cervical Ganglia.
  2. Along arteries arising from the Abdominal Aorta. Formed by postganglionic sympathetics arising from the Prevertebral Ganglia.
71
Q

Upon reaching the GI Tract, the postganglionic Sympathetics, which arose from Splanchnic nerves that synapsed at the prevertebral ganglia, contribute to formation of the ENTERIC NERVOUS SYSTEM within the walls of GI structures from the esophagus to the anal canal where they do what?

A

Remember: These are SYMPATHETIC neurons

  1. Facilitate contraction of smooth muscle sphincters
  2. Inhibit both peristalsis and glandular secretions
    - This binds up the excretory system, allowing more blood to be diverted to skeletal muscles.
72
Q

In the abdomen and pelvis nociceptors are stimulated by excessive distension in GI tract or bladder or by Strong contraction of smooth muscle in the wall of a visceral structure such as the uterus. What sensation is transmitted by Nocireceptors? What type of nerve fibers transmit this sensation to the CNS?

A
  • NOCICEPTORS transmit PAIN sensations

- VISCERAL AFFERENT (GVA) Fibers transmit the pain from the nociceptors from the Visceral Organs to the CNS.

73
Q

SPLANCHNICS convey GVA fibers in the abdomen and pelvis from viscera to the DORSAL ROOTS of spinal nerves T5-L2 via the WHITE COMMUNICATING RAMI. What might be an expected result if these GVA fibers are transmitting pain signals?

A

These pain afferents may stimulate GSA fibers in the Dorsal Roots of these nerves and produce AbdominoPelvic REFERRED PAIN!