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RUSVM Pharmacology > PNS drugs > Flashcards

PNS drugs Flashcards

1
Q

Albuterol

A

Selective beta 2 agonist
Bronchodilator
Tx lower airway disease
Inhaler use

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2
Q

Atenolol

A 
B1 selective antagonist
Longer half-life than propanolol
More selective for B1-receptors, lack of B2
Oral
Less side effects
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3
Q

Atropine

A 
Direct PSlytic
Anticholinergic/antimuscarinic
Tertiary compound - can cross BBB
Tx - bradyarrhythmias/bradycardia
Cardiac arrest - ~CPR
Tx - acetylcholinesterase tox
Tx cholinergic crisis
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4
Q

Bethanechol

A

PSmimetic
Muscarinic receptor agonist
ORAL
Contract urinary bladder destrusor m

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5
Q

Clenbuterol

A

Selective beta 2 agonist
Bronchodilator
Tx lower airway disease
Oral syrup - equine

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6
Q

Dopamine

A

Direct acting catecholamine Smimetic
Dose dependent action on dopamine receptors - at different alpha/beta
Low - dopamine agonist
Med/low - B1 - + inotrope
Med/high - B1 - + chronotrope, increase cardiac automaticity
High - A1 vasoconstriction

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7
Q

Edrophonium

Tensilon test

A

Indirect PSmimetic (reversible)
Fastest acting - shortest duration
Does NOT outlive the drug it reverses
Best use - test for MG

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8
Q

Ephedrine

A

Mixed (direct and indirect acting) Smimetic
Indirect increase in NE release and direct A1 and B activation
CRI BP maintainance under anesthesia
Increases BP - vasoconstriction and direct cardiac stimulation

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9
Q

Epinephrine

A

Direct acting catecholamine Smimetic

Competitive agonism at ALL A/B adrenergic

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10
Q

Esmolol

A

Ultra SHORT acting B1-antagonist
to test for B-blocker response
SELECTIVE

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11
Q

Glycopyrrolate

A

Direct acting PSlytic - anticholinergic
Quaternary compound - does NOT cross BBB
Slower onset - longer duration (than atropine)
Premed

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12
Q

Isoproterenol

A

Direct acting catecholamine Smimetic
Potent nonspecific B-agonist
Cardiac stimulatory effects and bronchodilation
Not commonly used

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13
Q

Neostigmine

A

Indirect PSmimetic - cholinergic (reversible - competitive inhibtion)
Reversal agent for competitive neuromuscular blockers NMB - ie. Reversal after needing to paralyze eye for surgery

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14
Q

Norepinephrine

A 
Direct acting catecholamine sympathomimetic
A1 agonism (NO B2 activity)
Vasopressor support - vasoconstriction
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15
Q

Oxybutynin

A

Direct acting PSlytic - anticholinergic
Can cross BBB
Relax detrusor m and allow bladder to fill - urinary antispasmodic

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16
Q

Phenoxybenzamine

A

Non-specific* A-antagonist - binds irreversibly (non-competitive)
SympathoLYTIC

Urinary retention due to urethral hypertonicity (relaxes sphincter)

Decreases BP - controls hypertension (Pheochromocytoma - adrenal medulla tumor)

17
Q

Phenylephrine

A

Direct acting A1 selective agonist
Increase peripheral vascular resistance through systemic vasoconstriction (can be severe)

Tx hypotension

18
Q

Phenylpropanolamine

Proin

A

Mixed (direct and indirect acting) sympathomimetic
Indirect increase in NE in bladder neck/urethra (primary action) and direct A1 agonist

Tx - urinary incontinence from urethral sphincter incompetence

19
Q

Prazosin

A

A1 antagonist
Urinary smooth m relaxation and vasodilation

FLUTD - urinary retention from urethral hypertonicity

Adjunctive Tx of congestive heart failure, systemic/pulmonary hypertension

20
Q

Propanolol

B blocker

A

Non-specific B-antagonist (B blocker)
Crosses BBB
Decrease SA node firing & AV conduction - bradycardia, dec cardiac output, O2 demand on heart

Tx tachyarrhythmias - chocolate, hyperthyroidism

21
Q

Propantheline

A

Direct acting PSlytics
Can NOT cross BBB
Relax detrusor m and allow bladder to fill - urinary antispasmodic
Tx AV block - bradyarrhythmias

22
Q

Pyridostigmine

A

Indirect PSmimetic - cholinergic (reversible)
Longer lasting than neostigmine (8-12 hours)
Long term maintenance therapy for MG

23
Q

Ractopamine

A

Non-selecctive agonism of beta 1, beta 2 beta 3

Increase lean muscle over fat

24
Q

Terbutaline

A

Selective beta 2 agonist
Bronchodilator
Tx lower airway disease
Tablet/injectable - small animal

25
Q

Zilpaterol

A

Non-selecctive agonism of beta 1, beta 2 beta 3

Increase lean muscle over fat

26
Q

Vasopressin

A

V1 - vascular smooth m
Vasoconstriction
Preferentially shunts blood to CNS & heart

V2 - endothelial cells, platelets, renal colleccting ducts (ADH)

27
Q

Dobutamine

A

Direct acting catecholamine sypathomimetic - synthetic beta 1 agonist
Positive inotropic effect
Hypotension (anesthesia)

RUSVM Pharmacology (3 decks)

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