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PMOC PDF 1 PART 1 > PMOC HISTORY > Flashcards

PMOC HISTORY Flashcards

1
Q

Shen Nung Traditional Chinese Medicine

A

Ch’ang shang, ma huang

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2
Q

Ch’ang shang use

A

Anti malarial

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3
Q

Ma huang use

A

Asthma and bronchitis

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4
Q

American Indians Drugs of Antiquity

A

Chaulmoogra fruit

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5
Q

Chaulmoogra fruit use

A

Management of leprosy

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6
Q

Brazil Drugs of Antiquity

A

Ipecacuanha root

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7
Q

Ipecacuanha root use

A

Dysentery and amebiasis

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8
Q

South American Indians drugs of antiquity

A

Coca leaves

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9
Q

Coca leaves is use for

A

Fatigue

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10
Q

Greek Apothecary

A

opium, squill, hyoscyamus, viper toxin, Cu, Zn ores, Fe sulfate, Cadmium oxide

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11
Q

Ma huang scientific name

A

Ephedra sinica

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12
Q

Paracelsus full name

A

Philippus Aureolus Theoprastus Bombastus Von Hohenheim

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13
Q

Paracelsus believe in what element that can cuse all disease

A

Sb- Antimony

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14
Q

He extracted morphine from poppy

A

Friedrich Sertürner

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15
Q

Doctrine that any drug capable of producing detrimental symptoms in healthy individuals will relieve similar symptoms occurring as an expression of disease.

A

“similia similibus curantur”

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16
Q

In 1810 he write the doctrine “similia similibus curantur”

A

Samuel Hahnemann

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17
Q

In 1816 he isolated emetine from Ipecacuanha

A

Pierre-Pelletier

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18
Q

What happen in 1820

A

Purification of caffeine, quinine and colchicine

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19
Q

what happen in 1826

A

Mass production of Quinine Sulfate

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20
Q

In 1845, he synthesize acetic acid

A

Adolph Kolbe

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21
Q

What happen in 1878

A

British pharmacologist John – concept of biological receptor

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22
Q

In 1886, what is the first alkaloid synthesis

A

Coniine

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23
Q

Side chain theory

A

Paul Ehrlich

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24
Q

First mass production of synthetic drug

A

Aspirin

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25
Q

He discover penicillin

A

Alexander Fleming

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26
Q

Penicillin SN

A

Penicillium notatatum

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27
Q

Quinine sulfate is use for

A

Anti malaria

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28
Q

Derived from hemlock

A

Coniine

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29
Q

First prodrug synthetic treatment for general bacterial infection

A

Prontosil/Sulfamidochrysoidine

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30
Q

He discover prontosil

A

Gerhard Domagk

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31
Q

What happen in year 1940

A

Bacteriostatic action of Sulfonamide like drugs

32
Q

single most important breakthrough in psychiatric treatment

A

Chlorpromazine

33
Q

Metabolite of iproniazid whic is for TB

A

Isoniazid

34
Q

first dibenzazepine and TCA

A

Imipramine

35
Q

First commercially successful SSRI

A

Fluoxetine

36
Q

He discover oxytocin

A

Henry dale

37
Q

It is use to induce labor

A

Oxytocin

38
Q

He discover thyroxine

A

Edward Kendall

39
Q

It is important for metabolism

A

Thyroid hormone

40
Q

Discover insulin

A

Charles Best and Frederick Banting

41
Q

He converted diosgenin to progesterone

A

Russel Marker

42
Q

He discover Norethindrone

A

Carl Djerassi

43
Q

It is an oral contraceptive

A

Norethindrone

44
Q

He discover progesterone + Norethindrone

A

John rock

45
Q

Norethindrone BN

A

Norminest

46
Q

It is an abortion pill

A

Mifepristone

47
Q

Contents of Levonorgestrel or Plan B

A

Mefepristone + Misoprostol

48
Q

dentist who administered Nitrous oxide during tooth extraction

A

Horace Wells

49
Q

Use ether as an anesthetic ageng

A

Crawford Long

50
Q

gave the first successful public demonstration of surgical anesthesia

A

William Morton

51
Q

used as anesthetic agent at St. Bartholomew’s Hospital

A

Chloroform

52
Q

Induces sleep

A

Laudanum

53
Q

Hypnotics and Anticonvulsants

A

Bromides, chloral hydrate, paraldehyde, urethane and sulfenal

54
Q

Adolph Von Beyer synthesize

A

5,5-diethylbarbituric acid

55
Q

Introduced Phenobarbital (Luminal)

A

Bayer Pharm

56
Q

Developed due to modification of the barbituric acid molecule

A

Hydantoins

57
Q

He isolated cocaine

A

Albert Niemann

58
Q

First to use cocaine for topical anesthesia in ophthalmological surgery

A

Carl Koller

59
Q

determined the structure of cocaine and atropine

A

Richard Willstater

60
Q

structural analogs of cocaine

A

Benzocaine, procaine, tetracaine and lidocaine

61
Q

discovered Digitalis purpurea was beneficial to those suffering from abnormal fluid buildup

A

William Withering

62
Q

isolated digitoxin

A

E. Humolle and T. Quevenne

63
Q

discovered the first anticholesterol drug

A

Akira Endo

64
Q

discovered Lovastatin

A

Merck

65
Q

isolated digoxin

A

Sydney Smith

66
Q

Digitoxin BN

A

Lanoxin

67
Q

used for leukemia therapy

A

Sulfur mustard and nitrogen mustard

68
Q

first effective leukemia, discovered by

A

6 -mercaptopurine Gertrude Elion

69
Q

Gold standard for cancer

A

Cisplatin

70
Q

Paclitaxel discovered by

A

Moeroe Wall and Masukh Wani

71
Q

Pacific Yew Tree

European Yew Tree

A

Taxus brevifolia

Taxus bacatta

72
Q

Widely use cardiac glycoside

A

Digoxin

73
Q

A scientific discipline at the intersection of chemistry and pharmacy involved with designing, synthesizing and developing pharmaceutical drugs.
It also includes the study of existing drugs, their biological properties, and their Quantitative Structure-Activity Relationships (QSAR).

A

Organic Pharmaceutical Chemistry

74
Q

Involves the identification, synthesis and development of new chemical entities suitable for therapeutic use.

A

Medicinal Chemistry

75
Q

Focused on quality aspects of medicines and aims to assure fitness for the purpose of medicinal products

A

Pharmaceutical Chemistry

76
Q

is a strategy of the essential importance for chemistry and pharmacy, based on the idea that when we change a structure of a molecule then also the activity or property of the substance will be modified.

A

Quantitative Structure-Activity Relationships (QSAR)

77
Q

includes synthesis, isolation, fermentation, screening, SAR studies

A

Discovery phase

PMOC PDF 1 PART 1 (5 decks)

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