Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

PMI > PMI03-2024 Wound Healing > Flashcards

PMI03-2024 Wound Healing Flashcards

1
Q

what is regeneration?

A

The replacement of lost or damaged tissue by that of a similar type derived from the proliferation of the surrounding undamaged cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Which organ can regenerate itself?

A

liver

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is repair?

A

Replacement of lost of damaged tissue by granulation tissue which later matures into fibrous scar tissue

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What are the two types of healing?

A

Primary intention

secondary intention

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What are the 4 stages of healing?

A

Haemostasis
Inflammation
Proliferation
Remodelling

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What is the wound like in primary intention?

A

The wound edges are in close apposition

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is the wound like in secondary intention?

A

Wound is more extensive and the wound edges are widely separated

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

When will primary intention occur?

A

Occurs in wounds with dermal edges and these edges are brought together so that they are adjacent with each other
When the wound is precise with minimal disturbance to local tissue and epithelial basement membrane

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is the difference between primary and secondary intention?

A

Primary is faster and produces less scarring

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

When does secondary intention occur?

A

Wound is more extensive and wound edges are not in close proximity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What direction does the wound heal in secondary intention?

A

From the bottom upwards

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What covers the wound in secondary intention?

A

Granulation tissue

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What occurs during haemostasis?

A

Platelets and cytokines form a haematoma and cause vasoconstriction
This limits blood loss from the affected area
Platelet plug formation and fibrin clot formation are the end results of this phase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

How does the closer the proximity of the wound edges affect the clot?

A

The closer the proximity of the wound edges, the easier the formation of a clot and prevent infection by forming a scab

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What factors affect the haemostasis stage?

A

Aspirin
Warfarin
Factor VIII deficiency

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What occurs during inflammation?

A

Removes any cell debris and pathogens

17
Q

What occurs during proliferation?

A

Proliferation of fibroblasts and endothelial cells lead to the formation of granulation tissue
New blood vessels migrate from the wound edges
The small blood vessels are accompanied by fibroblasts and inflammatory cells
The production of collagen in the ECM by fibroblasts allows for the closure of the wound after one week

18
Q

What type of tissue is granulation tissue?

A

Loose cellular connective tissue

19
Q

What occurs during remodelling?

A

Decreased cellularity and decreased vascularity

Remodelling of collagen matrix as there is collagen cross linking

20
Q

What is the end result of primary intention healing?

A

Complete return to function, with minimal scarring and loss of appendages

21
Q

What occurs during re-epithelialisation?

A

Proliferation of the basal epithelial cells adjacent to the wound
Basal cells then migrate to across the wound bed under the fibrin scab to restore the epithelial community
Epithelial cells differentiate and stratified squamous structures reform

22
Q

When does haemostasis and platelet plug and clot formation occur?

A

1 hour after injury

23
Q

When does inflammation occur?

A

48 hours after injury

24
Q

When does granulation tissue form?

A

2-5 days after injury

25
Q

When does maturation, remodelling and wound contraction occur?

A

More than 5 days after injury

26
Q

When does re-epithelialisation occur?

A

1-3 days after injury

27
Q

What local factors affect wound healing?

A 
Type, size and location of the wound
Local blood supply
Infection 
Foreign material/ contamination
Radiation damage
28
Q

What systemic factor affect wound healing?

A

Increasing age
Obesity
Nutritional status (vitamin C deficiency)
Medical conditions (diabetes, CV disease)

29
Q

What are complications of wound healing?

A

Wound dehiscence- wound rupturing following surgical suturing
Contractures- the pattern of wound contraction can cause issues
Keloid/ hypertrophic scar formation following excessive collagen production
Weak scars
Pigmentation

30
Q

What is a keloid scar?

A

Sharpely elevated progressively enlarging scar
Due to the formation of excess collagen in the dermis during connective tissue repair
May spread beyond the margins of the original wound

31
Q

Do keloid and hypertrophic scaring affect the face?

A

Seen on face but does not affect the oral mucosa

32
Q

What is hypertrophic scarring?

A

Similar to keloid but does not spread beyond wound margins

PMI (16 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions