PM test 1 Flashcards
toxicology is
One of the Oldest scientific disciplines and dervived from the word toxicon
Who passed the 1st law banning poisoning
Roman Empire
Arsenic Act
Father of toxicology
Paracelsus Dose makes the poison
all things are poison, and nothing is without poison, only dose permits something not to be poisonous
Six categories of sources of artifacts
o Pre-analytical
o Container/specimen storage
o Analytical
o Prior medical therapy
o Medical intervention
o Tissue donation
Blind stick
Hit the esophagus
Stomach contaimination due to gastric rupture
increase in drug concetration
potential to misintrepratiatin of cause of death
agonal vomiting
common in death
volatile compounds that may be added to a blood sample collected in a serum separator tube
Toluene , Ethylbenzene, xylenes
Vacutainer effect
Trycyclic antidepressant ]
Vacutainer effect decrease in concentration due to absorption adherence to the rubber stop
What impurity may be added to a sample with the use of a deuterated internal standard
native drug in the deuterated internal standard
1% Methanolic HCl may oxidize some drugs
true in light it may be oxidized
List drug or drug class that may be lost in the dry-down process of drug extraction**
methamphetamine/amphetamine
What type of vacutainer tube will lead to the in vitro formation of GHB
Citrate tubes
What is a source of general laboratory contamination and how would it be prevented/detected?
Glassware- get new glassware and detect through blanks and control
Autosampler- detect through blanks and control
Elevated gas chromatograph injector port temperature will have no impact on process induced artifacts
False, over 180C was bad
Why is cocaine is used for lacrimal or ENT surgeries
Anesthetic effects and vasoconstriction
After therapeutic use of coaine in surgical procedures, a urine test for cocaine metabolites may remiane postive for as long as
72 hours
Deaths have been associated with the topical application of diphenhydramine
true usually in child
What external anatomical findings may indicate a transdermal patch might have been used
Adhesive outline
Gastric Lavage
physicla removal of drug so there will be a decrease in drug concetration
Fluid Resucitation
central IV line directly to heart which will dilute the drug so it will also decrease the concentration of drug
Medications that may be administered using a transdermal patch and/or an intrathecal patch
Fentanyl morphine nicotine estrogen
How will oxygen therapy impact carbon monoxide measurement and interpretation
Oxygen therapy floods the body with oxygen to replace the carbon monoxide from hemoglobin so you get decrease in the concentration of carboxyhemoglobin.
decrease the half life
get false measurements of how much CO there was
What common contaminate that may be found following a corneal procurement in vitreous fluid
Isopropyl alcohol and acetone
Describe/ discuss various types of evidence and information collected during a death scene investigation and its use
Social Media- identification, sucide note, others intent, last time/date on S/M
Family interviews- patient medical records, history of drug abuse, depression triggers, jail time
Physical- out of place items, pills, syringes, rx bottle
Weather-hypo/hyperthermia
All drug death leave specific/diagnostic anatomical findings
False, non-specific
A perforated nasal septum is associated with what drug of abuse and what is the mechanism
Cocaine use
the blood vessels will shrink and repeated use will cause the blood vessels to shrink and die
Meth mouth
Rampart dental carries icky teeth/loss of teeth
methamphetamine
Mee lines may be caused by
Heavy metals/arsenic
What body color is commonly associated with carbon monoxide poisoning
cherry red
bitter almond smell can be smelled by everyone
false genetic related
A comibined lung weight of… is associated with intoxication by a narcotic or other CNS depressant drugs
1000g
Foam cone is associated with what drugs of abuse
Opioids and CNS depressant narocotics OD morphine,
causes of increased lung weight
CPR, infection, drowning
What vitreous glucose concetration is associated with hyperglcemia
greater tahn or wequla to 200
Vitreous potassium concentrations can be used to determine the PM interval
False, blood?
Four PM clinical chemistry electrolyte patterns **
- Dehydration Pattern
- Uremic Pattern
- Low Salt Pattern
- Decomposition Pattern
Accidental salt poisoning
Gargling
Salt out
treatment of burns
exorcism
Urine GHB concentration of 100mg/L is consistent with antemortem exposure
True greater than 50mg/L
A positive morphine finding in urine may be due to the ingestion of serval poppy seed bagels
True
