PM test 1

Question 1

toxicology is

Answer 1

One of the Oldest scientific disciplines and dervived from the word toxicon

Question 2

Who passed the 1st law banning poisoning

Answer 2

Roman Empire
Arsenic Act

Question 3

Father of toxicology

Answer 3

Paracelsus Dose makes the poison
all things are poison, and nothing is without poison, only dose permits something not to be poisonous

Question 4

Six categories of sources of artifacts

Answer 4

o Pre-analytical
o Container/specimen storage
o Analytical
o Prior medical therapy
o Medical intervention
o Tissue donation

Question 5

Blind stick

Answer 5

Hit the esophagus
Stomach contaimination due to gastric rupture
increase in drug concetration
potential to misintrepratiatin of cause of death

Question 6

agonal vomiting

Answer 6

common in death

Question 7

volatile compounds that may be added to a blood sample collected in a serum separator tube

Answer 7

Toluene , Ethylbenzene, xylenes

Question 8

Vacutainer effect

Answer 8

Trycyclic antidepressant ]
Vacutainer effect decrease in concentration due to absorption adherence to the rubber stop

Question 9

What impurity may be added to a sample with the use of a deuterated internal standard

Answer 9

native drug in the deuterated internal standard

Question 10

1% Methanolic HCl may oxidize some drugs

Answer 10

true in light it may be oxidized

Question 11

List drug or drug class that may be lost in the dry-down process of drug extraction**

Answer 11

methamphetamine/amphetamine

Question 12

What type of vacutainer tube will lead to the in vitro formation of GHB

Answer 12

Citrate tubes

Question 13

What is a source of general laboratory contamination and how would it be prevented/detected?

Answer 13

Glassware- get new glassware and detect through blanks and control
Autosampler- detect through blanks and control

Question 14

Elevated gas chromatograph injector port temperature will have no impact on process induced artifacts

Answer 14

False, over 180C was bad

Question 15

Why is cocaine is used for lacrimal or ENT surgeries

Answer 15

Anesthetic effects and vasoconstriction

Question 16

After therapeutic use of coaine in surgical procedures, a urine test for cocaine metabolites may remiane postive for as long as

Answer 16

72 hours

Question 17

Deaths have been associated with the topical application of diphenhydramine

Answer 17

true usually in child

Question 18

What external anatomical findings may indicate a transdermal patch might have been used

Answer 18

Adhesive outline

Question 19

Gastric Lavage

Answer 19

physicla removal of drug so there will be a decrease in drug concetration

Question 20

Fluid Resucitation

Answer 20

central IV line directly to heart which will dilute the drug so it will also decrease the concentration of drug

Question 21

Medications that may be administered using a transdermal patch and/or an intrathecal patch

Answer 21

Fentanyl morphine nicotine estrogen

Question 22

How will oxygen therapy impact carbon monoxide measurement and interpretation

Answer 22

Oxygen therapy floods the body with oxygen to replace the carbon monoxide from hemoglobin so you get decrease in the concentration of carboxyhemoglobin.
decrease the half life
get false measurements of how much CO there was

Question 23

What common contaminate that may be found following a corneal procurement in vitreous fluid

Answer 23

Isopropyl alcohol and acetone

Question 24

Describe/ discuss various types of evidence and information collected during a death scene investigation and its use

Answer 24

Social Media- identification, sucide note, others intent, last time/date on S/M
Family interviews- patient medical records, history of drug abuse, depression triggers, jail time
Physical- out of place items, pills, syringes, rx bottle
Weather-hypo/hyperthermia

Question 25

All drug death leave specific/diagnostic anatomical findings

Answer 25

False, non-specific

Question 26

A perforated nasal septum is associated with what drug of abuse and what is the mechanism

Answer 26

Cocaine use
the blood vessels will shrink and repeated use will cause the blood vessels to shrink and die

Question 27

Meth mouth

Answer 27

Rampart dental carries icky teeth/loss of teeth
methamphetamine

Question 28

Mee lines may be caused by

Answer 28

Heavy metals/arsenic

Question 29

What body color is commonly associated with carbon monoxide poisoning

Answer 29

cherry red

Question 30

bitter almond smell can be smelled by everyone

Answer 30

false genetic related

Question 31

A comibined lung weight of… is associated with intoxication by a narcotic or other CNS depressant drugs

Answer 31

1000g

Question 32

Foam cone is associated with what drugs of abuse

Answer 32

Opioids and CNS depressant narocotics OD morphine,

Question 33

causes of increased lung weight

Answer 33

CPR, infection, drowning

Question 34

What vitreous glucose concetration is associated with hyperglcemia

Answer 34

greater tahn or wequla to 200

Question 35

Vitreous potassium concentrations can be used to determine the PM interval

Answer 35

False, blood?

Question 36

Four PM clinical chemistry electrolyte patterns **

Answer 36

1. Dehydration Pattern
2. Uremic Pattern
3. Low Salt Pattern
4. Decomposition Pattern

Question 37

Accidental salt poisoning

Answer 37

Gargling
Salt out
treatment of burns
exorcism

Question 38

Urine GHB concentration of 100mg/L is consistent with antemortem exposure

Answer 38

True greater than 50mg/L

Question 39

A positive morphine finding in urine may be due to the ingestion of serval poppy seed bagels

Answer 39

True