Extra potential questins Flashcards
Drug concentration may be artificially changed due to
Collection process
Storage conditions
Container
Targeted analytes may be added to the specimen from the container
Agonal vomitus
All should have been negative
ETOH and drug [] in aortic blood were higher than in the left heart
Suggesting direct diffusion into these vessels rather than diffusion via the pulmonary and cardiac blood
Potential sources of solvent artifact
Butyl rubber stoppers
Serum separator tube gels
Compounds introduced during manufacturing process
Drugs affected by SST
Lidocaine, Benzoylecgonine
SST
Decrease was a function of time and sample volume
Decreases were due to the absorption of drugs into gel barrier
Volatility durig dry down
Meth/amp
Phencyclidine
Fenfluramine
ALkylated Barbiturates
what info should you get for medical intervention
Including time of intervention relative to the time of sampling
Hospital or autopsy samples
Type of intervention
Rationale for intervention
Types of tissue recovery
non and beting heart
Levamisole in cocaine user
anthelmintic [dewormer] agent for use in animals, is a common additive in cocaine and is speculated to enhance the euphoric effect
purple facial hair and ears
Rohypnol color
Blue
Pharmacobezors
Mass of any form of unabsorbed material within the GI tract
end to form at anatomic strictures – between esophagus and rectum
What is often the only clue and most important for drug overdose
pulmonary congestion and edema
Four patterns of electrolytes
Dehydration- rise in sodium and chloride
Uremic-ure and creatinine increase
low salt-low sodium and chloride levels
Decomp- High potassium levels
Analytes tested in blood
Ketones
Creatinine
Hemoglobin A1C
Tryptase
MArsch Test
sample placed in flask with Zinc and sulfuric acid. Arsine ghas form and deposit on mirror
Reinsh test
replace copper with another element below in electrochemical series and discoloring copper
Drug affected by chemnical instability
cocaine morphone
Facotr affecting rate of putrefaction
ambient temp humidity
four stages of decomp
autolysis
bloating
active decay
skeletonization
Bariatric Surgery- Gastric by-pass
Most efficient method to tx morbid obesity
Complaints of increased sensitivity of reduced tolerance to EtOH as compared to pre-surgical state
Reduction in body weight [20 – 40% within 1-2 years]
Increased dose per Kg of body weight
Rapid absorption of EtOH
Higher Cmax
Earlier Tmax
