Pleural disease Flashcards
What is a pleural effusion?
This is a collection of fluid in the plerual space
What are the different types of pleural effusion?
- Transudate - due to pressure differences
- Exudate - due to inflammatory process
What can cause a transudative pleural effusion?
- LVF
- Liver Cirrhosis
- Hypoalbuminaemia
- Peritoneal Dialysis
- Hypothyroidism
- Nephrotic Syndrome
- Mitral syndrome
- Pulmonary Embolism
- Constrictive Pericarditis
- Ovarian hyperstimulation syndrome
What can cause exudative pleural effusion?
- Malignancy
- Parapneumonic
- Pulmonary embolism/infarction
- Rheumatoid arthritis
- Autoimmune diseases
- Benign asbestos effusion
- Pancreatitis
- Post-myocardial infarction/cardiotomy syndrome
- Yellow nail syndrome
- Drugs
What are the symptoms of a pleural effusion?
- Asymptomatic
- Dyspnoea
- Pleuritic chest pain
What are clinical signs of a pleural effusion?
Generally only in effusions > 500ml
- Decreased expansion
- Stony dull percussion note
- Diminished breath sounds
- Decreased tactile vocal fremitus
- Decreased vocal resonance
- Bronchial breathing - above where lung is compressed by effusion
- Tracheal deviation - very large effusions
Why do you get reduced breath sounds in a pleural effusion?
Breath sounds are related to the intensity of flow (sound energy) as well as the transmission of the sounds through the lungs and chest wall. Abnormalities of either element will diminish breath sounds. Pleural fluid between the airways and stethoscope reduces transmission
Why do you get stony dull percussion in a pleural effusion?
Pleural fluid dampens the normal resonance of the lung fields, creating the characteristic ‘stony’ dullness.
What else would you look for if you suspected a pleural effusion?
Signs of a cause
- Malignancy - cachexia, clubbing, lymphadenopathy
- Chronic liver disease
- Cardiac failure
- Hypothyroidism
- RA
- SLE signs
How would you investigate a pleural effusion?
- CXR
- CT
- Aspiration
- Biopsy
What complications can occur from aspirating a pleural effusion?
- Pneumothorax
- Empyema
- Pulmonary oedema
- Vagal reflex
- Air embolism
- Tumour cell seeding
- Haemothorax
If, when aspirating a pleural effusion, a foul smelling fluid was aspirated, what might you suspect to be the cause?
Anaerobic empyema
If, when aspirating a pleural effusion, you aspirated food particles in pleural fluid, what might suspect?
Oesophageal rupture
If, when aspirating a pleural effusion, you obtained a milky coloured fluid, what might you suspect?
Chylothorax
What investigations might you want to get done on a pleural fluid sample?
Depends on clinical picture
- Gross analysis
- Cytology
- Clinical chemistry
- Immunology
- Microbiology
What might a bloody pleural effusion indicate?
- Trauma
- Malignancy
- Pulmonary infarction
If, on biochemical analysis of a pleural fluid sample, the protein level was found to be < 25g/L, what type of effusion would this be?
Transudate
If, on biochemical analysis of a pleural fluid sample, the protein level was found to be > 35g/L, what type of effusion would this be?
Exudate
What could cause a glucose of <3.3 mmol/L in a pleural fluid sample?
- Empyema
- Malignancy
- TB
- RA
- SLE
What could cayse a pH of < 7.2 in a pleural fluid sample?
- Empyema
- Malignancy
- RA
- SLE
- TB
What could cause a raised LDH in a pleural fluid sample?
- Empyema
- Malignancy
- TB
- RA
- SLE
How would you manage a pleural effusion?
- Treat the cause
- Drainage
- Pleurodesis
- Surgery