Chronic bronchitis, emphysema and COPD Flashcards
What is the definition of bronchitis?
The inflammation of mucus membranes in the bronchial passages. This can either be acute (lasting from one to three weeks) or chronic (lasting at least 3 months of the year, 2 years in a row).
How is chronic bronchitis clinically defined?
Clinically defined as a productive cough (sputum) most days in at least 3 consecutive months for two or more consecutive years, without other underlying disease
What tends to cause chronic bronchitis?
Overexposure to lung irritants (e.g. tobacco exposure)
What is the pathophysiology of chronic bronchitis?
Due to sustained inflammation, physiological and functional changes occur which result in mucus hyper secretion (hypertrophy of mucus-secreting glands and hyperplasia of goblet cells). The combination of inflammation of the airways and mucus hypersecretion leads to obstruction to airflow through narrowing of the airways and excessive mucus.
What pathological findings do you see in chronic bronchitis?
Large airways
- Mucous gland hypertrophy/hyperplasia
- Goblet cell (secrete mucins) hyperplasia
- Inflammation and fibrosis
Small airways
- Goblet cell appearance - Goblet cells are not normally found in the smaller airways.
- Inflammation and fibrosis.
What is emphysema?
A permanent increase in size of airspaces distal to the terminal bronchiole beyond their normal capacity. This arises either from dilatation or from destruction of the walls of the airspaces without obvious fibrosis.
How does emphysema occur?
It arises from destruction of alveoli beyond the terminal bronchiole. The alveoli (with their elastic fibres) hold the bronchiole open, similar to the way tent ropes hold up an awning. Destruction of the alveoli results in loss of elastic support, meaning the bronchioles become progressively collapsible, especially on expiration.
In severe cases, entire acini are lost, and large bullae form in the lung parenchyma.
How is emphysema classified pathologically?
- Centriacinar
- Panacinar
- Periacinar
- Irregular
- Bullous
What is centriacinar emphysema?
Distension and damage is concentrated around the respiratory bronchioles, while more distal alveolar ducts and alveoli remain intact.
Very common; severe cases associated with limited airflow. It begins with bronchiolar dilatation, and then alveolar tissue loss.
What is panacinar emphysema?
Damage and distension affects the whole acinus (portion of the lung distal to a terminal bronchiole). This results in severe airflow and V/Q mismatch.
What deficiency is panacinar emphysema associated with?
Alpha-1 antitrypsin deficiency
What is periacinar emphysema?
Enlarged air spaces along the edge of the acinar unit, but only where it abuts against fixed structures such as pleura and vessels.
What are emphysematous bullae?
These are emphysematous space becomes greater than 1cm
How does smoking cause emphysema?
Chemicals in tobacco smoke cause an imbalance in the protease-antiprotease control system. Cigarette smoke encourages neutrophils to infiltrate the airways. It’s also thought to inhibit alpha1-antitrypsin activity.
What contributes to the development of emphysema?
- Smoking
- Ageing
- Alpha1-antitrypsin deficiency
What is cor pulmonale?
Hypertrophy of the Right Ventricle resulting from disease affecting the function and/or the structure of the lung (Chronic lung disease which leads to chronic hypoxaemia).
How does cor pulmonale occur?
Chronic lung disease which leads to chronic hypoxaemia. This in turn causes vasoconstriction to occur across the entirety of the lung, increasing overall vascular pressure. This creates back pressure against the action of the heart, causing it to work harder, which causes the right ventricle to hypertrophy.
This can lead to cardiac failure as the heart begins to dilate.
If you saw this in someone with chronic lung diseasae, what might you suspect is happening?
Development of cor pulmonale
What blood changes may you see in someone with chronic hypoxaemia?
Polycythaemia
If you saw cor pulmonale on X-ray, what different causes would you think of?
- COPD
- Hypoventilation syndromes - scoliosis, neuromuscular disease, obesity
- ILD
- Long term high altitude exposure
Why do individuals get fluid overload in cor pulmonale?
Hypoxia is sensed by kidneys and carotid bodies, which increases sympathetic activity and renal vasoconstriction. Sympathetic activation (plus other mechanisms) leads to renal retention of salt and water. In the context of chronic hypoxia, vasculature becomes more permeable, which leads to fluid extravasation.
This, combined with increased fluid volume, presents clinically as increased JVP and ankle oedema. These features are not due to impaired cardiac output
What is Chronic obstructive pulmonary disease?
Chronic obstructive pulmonary disease (COPD) is a chronic, slowly progressive disorder characterised by airflow obstruction that does not change markedly over several months. Most of the lung function impairment is fixed, although some reversibility can be produced by bronchodilator (or other) therapy
What are thought to be the causes of COPD?
- Smoking (85-95%)
- Chronic asthma
- Air pollution
- Occupation
- Alpha1-antitrypsin deficiency
What is the general pathology of COPD?
- Mucus gland hyperplasia
- Chronic inflammation and fibrosis
- Emphysema
- Thickened pulmonary arteriolar wall and remodelling
What are symptoms of COPD?
- Dyspnoea - exertional
- Chronic cough - may be productive
- Decreased exercise tolerance
- Wheeze
- Chest tightness
- Peripheral oedema
- Orthopnoea
What colour is the sputum produced by someone with COPD?
Clear or mucoid
What signs may you see in someone with COPD?
- Cyanosis
- Asterixis - CO2 retention
- Barrel chest
- Decreased chest expansion
- Tachypnoea
- Pursed lip breathing
- Quiet breath sounds +/- wheeze
- Quiet heart sounds - due to lung hyperinflation
- Signs of cor pulmonale
- Paradoxical breathing
- Tracheal tug
What might you see in someone with COPD that uses ß2 agonist?
Fine tremor
What are signs of Cor pulmonale?
- Increased JVP
- Hepatomegaly
- Ascites
- Ankle oedema
What are signs of chronic CO2 retention?
- Warm peripheries
- Plethoric conjunctivae
- Bounding pulse
- Possible Asterixis
What is pursed lip breathing?
A breathing practice, often taught, which includes a long, slow expiration against pursed lips.
What is the mechanism behind pursed lip breathing?
Pursing the lips allows the patient to breathe against resistance, thus maintaining a slow exhalation back pressure within the lungs. This helps keep bronchioles and small airways open for much-needed oxygen exchange. As such, it allows deeper breathing and improved V/Q matching
What is barrel chest?
A ratio of anteroposterior (AP) to lateral chest diameter of greater than 0.9. The normal AP diameter should be less than the lateral diameter and the ratio of AP to lateral should lie between 0.70 and 0.75.
What is the mechanism behind the development of a barrell chest?
Considered to be due to over-activity of the scalene and sternocleidomastoid muscles, which lift the upper ribs and sternum. With time, this overuse causes remodelling of the chest.
In chronic obstructive pulmonary disease, there is a chronic airflow limitation that results in increased end-expiratory volumes and chronic hyperinflation.
Chronic hyperinflation reduces airway resistance and improves elastic recoil at the expense of higher lung volumes. Over time this leads to chest wall remodelling and barrel chest abnormality.