Pleural Disease

Question 1

Drugs that cause eosinophilic pleural effusion

Answer 1

Warfarin, nitrofurantoin, and propylthiouracil

Question 2

Latency period for benign asbestos pleural effusion to develop

Answer 2

15 to 48 years

Question 3

Triglyceride and cholesterol cut-offs for chylothorax

Answer 3

TG >110 and cholesterol <200

Question 4

Conservative therapy for chylothorax should include these two pharmacotherapies

Answer 4

Somatostatin or octreotide

Question 5

If chylothorax is draining more than ____mls per day, surgical treatment should be considered

Answer 5

1000mls

Question 6

First step in managing chylothorax

Answer 6

Conservative management with chest tube drainage and treatment of the underlying cause

Question 7

Mutations in the ____ gene have been associated with LAM

Answer 7

mTOR

Question 8

Renal abnormality associated with LAM

Answer 8

Renal angiomyolipomas

Question 9

Stain that confirms diagnosis of LAM

Answer 9

HMB-45 staining

Question 10

Elevated levels of ____ in the serum have been associated with LAM

Answer 10

VEGF-D (greater than 800 assoc with LAM)

Question 11

Sirolimus MOA

Answer 11

mTOR inhibitor

Question 12

Most common cause of eosinophilic pleural effusion

Answer 12

Air or blood in the pleural space

Question 13

Eosinophil cutoff for eosinophilic pleural effusion

Answer 13

> 10%

Question 14

TTF-1 is associated with which type of lung cancer?

Answer 14

Lung adenocarcinoma

Question 15

Napsin is associated with which type of lung cancer

Answer 15

Lung adenocarcinoma

Question 16

CK7 is associated with which type of lung cancer

Answer 16

Lung adenocarcinoma

Question 17

p40 is associated with which type of lung cancer

Answer 17

Lung SCC

Question 18

p63 is associated with which type of lung cancer

Answer 18

Lung SCC

Question 19

CK5/6 is associated with which type of lung cancer

Answer 19

Lung SCC

Question 20

MELD score needed for transplant referral

Answer 20

> 15

Question 21

Pleural fluid exposure to air will ____ the pH

Answer 21

Increase

Question 22

Lidocaine in the pleural fluid analysis will _____ the pH

Answer 22

Decrease

Question 23

______ is a rare diagnosis associated with SLE that leads to progressive dyspnea and reduction in TLC. This can also have impaired diaphragmatic excursion and low NIF.

Answer 23

Shrinking lung syndrome

Question 24

Pleural lipomas typically have houndsfield units between

Answer 24

(-)50 and (-)150