Pleural Disease Flashcards
Drugs that cause eosinophilic pleural effusion
Warfarin, nitrofurantoin, and propylthiouracil
Latency period for benign asbestos pleural effusion to develop
15 to 48 years
Triglyceride and cholesterol cut-offs for chylothorax
TG >110 and cholesterol <200
Conservative therapy for chylothorax should include these two pharmacotherapies
Somatostatin or octreotide
If chylothorax is draining more than ____mls per day, surgical treatment should be considered
1000mls
First step in managing chylothorax
Conservative management with chest tube drainage and treatment of the underlying cause
Mutations in the ____ gene have been associated with LAM
mTOR
Renal abnormality associated with LAM
Renal angiomyolipomas
Stain that confirms diagnosis of LAM
HMB-45 staining
Elevated levels of ____ in the serum have been associated with LAM
VEGF-D (greater than 800 assoc with LAM)
Sirolimus MOA
mTOR inhibitor
Most common cause of eosinophilic pleural effusion
Air or blood in the pleural space
Eosinophil cutoff for eosinophilic pleural effusion
> 10%
TTF-1 is associated with which type of lung cancer?
Lung adenocarcinoma
Napsin is associated with which type of lung cancer
Lung adenocarcinoma
CK7 is associated with which type of lung cancer
Lung adenocarcinoma
p40 is associated with which type of lung cancer
Lung SCC
p63 is associated with which type of lung cancer
Lung SCC
CK5/6 is associated with which type of lung cancer
Lung SCC
MELD score needed for transplant referral
> 15
Pleural fluid exposure to air will ____ the pH
Increase
Lidocaine in the pleural fluid analysis will _____ the pH
Decrease
______ is a rare diagnosis associated with SLE that leads to progressive dyspnea and reduction in TLC. This can also have impaired diaphragmatic excursion and low NIF.
Shrinking lung syndrome
Pleural lipomas typically have houndsfield units between
(-)50 and (-)150
