Pleura, chest wall, diaphragm and miscellaneous chest disorders Flashcards
Parietal and visceral pleura meet at the
Hila
Thin double layered fold at the medial lung base inferior to the inferior pulmonary veins termed the
Pulmonary ligament
Normal amount of fluid in the pleural space
2-5 ml
Formation of pleural fluid follows
Starling law and depends upon hydrostatic and oncotic forces in both systemic capillaries of the parietal pleura and pleural space
Under normal conditions, pleural fluid is formed by
Filtration from systemic capillaries in the parietal pleura and resorbed via parietal pleural lymphatics
Most common condition to produce a transudative pleural effusion
Congestive heart failure
Unilateral effusion is more common on what side
Right
Chf produce unilateral or bilateral PE?
Bilateral
3 Parenchymal infections that typically result in empyema formation are
Bacterial pneumonia,
septic emboli,
lung abscess
2 Most common causes of parapneumonic effusion and empyema
Staph aureus and gram neg pneumonias
Stage of PPE: visceral pleura inflammation causes increased capillary permeability and pleural fluid accumulation
Stage 1 exudative
Stage of PPE: develops 2-3 weeks after initial pleural fluid formation and is characterized by ingrowth of fibroblasts over the pleura, which produces pleural fibrosis and entraps lung
Stage 3 parapneumonic effusion
Stage of PPE: fibrinopurulent pleural fluid collection containing bacteria and neutrophils.fibrin deposition on the visceral and parietal pleura impairs fluid resorption and produces loculations
Stage 2
Effusion in TB are more common in what group of people?
Young adults with pulmonary disease and HIV positive individuals with severe immunodeficiency
Pleural fluid composition in TB
Straw colored, greater than 70% lymphocytes and a low glucose concentration
Mechanism of effusion in CHF, parapneumonic efffusion, permeability pulmonary edema, lung transplantation
Increased interstitial fluid production
Type of effusion in CHF, PPE, permeability pulmonary edema and lung transplantation
Transudate
Mechanism of effusion in LV or RV failure, SVC syndrome, pericardial tamponade
Increased hydrostatic pressure
Type of effusion in LV or RV failure, SVC syndrome, pericardial tamponade
Transudate
Increased capillary permeability produces what type of effusion
Exudative
Mechanism and type of effusion in low protein states
Decreased capillary oncotic pressure, transudative
Mechanism and type of effusion in malignancy
Impaired fluid resorption, exudative
Elevated systemic venous pressure produces what type of effusion
Transudative
On CT, it is elliptic in shape and is seen most often within the posterior (costal pleura) and inferior (subpulmonic) pleural space
Empyema
Treatment of empyema
External drainage
Treatment for lung abscess
Postural drainage and antibiotics
Effusions that have intrinsic high attenuation or the presence of a fluid-fluid level caused by dependent cellular blood elements represents
Hemorrhagic effusions
Cardiogenic, hypoproteinemic, myxedematous, cirrhotic and nephrotic syndrome produce what type of effusion
Transudative
Infecfion, infarction, neoplasm and inflammation produce what type of effusion
Exudative
6 Tumors most commonly associated with PE (in order)
Lung carcinoma > breast carcinoma > pelvic tumor > gastric cancer > lymphoma
Shape of empyema as compared with lung abscess
Empyema- oval; lung abscess- round
Margin of empyema as compared to lung abscess
Empyema- thin, smooth (split pleura sign); lung abscess- thick and irregular
Angle with chest wall of empyema as compared to lung abscess
Empyema- obtuse; lung abscess- acute
Effect on lung of empyema as compared to lung abscess
Empyema- compression; lung abscess- consumption
Hemothorax produce CT attenuation more than
80 HU
Acute hemothorax is treated by
Thoracostomy tube
Treatment of hemothorax with persistent bleeding or hypotension
Thoracotomy
Esophageal perforatjon from prolonged vomiting (boerhaave syndrome) or as complication of esophageal dilatation may produce a pleural effusion, most commonly on what side
Left
Elevated salivary amylase levels, low pH within the pleural fluid is diagnostic for
Esophageal perforation
PE in SLE is of what type, and is usually associated with (7)
Exudative;
pleuritic chest pain, cardiomegaly, pericardial effusion, hypertension, renal failure or lupus associated endocarditis or myocarditis
Most common intrathoracic manifestation of RA and is frequently seen in male patients following the onset of joint disease
Pleural effusion
True or false: PE in RA may occur independently from pulmonary parenchymal involvement
True
Effusions in RA are what type
Exudative
True or false: rheumatoid effusions may persist unchanged for years
True
Autoimmune syndromes producing pleural or pericardial effusions have been described following
Myocardial infarction ( dressler syndrome) or cardiac surgery (postpericardiotomy syndrome)
Autoimmune syndromes (Dressler and postpericardiotomy syndromes) produce what type of effusion
Serosanguinous exudative
peritoneal fluid may enter the pleural space via
transdiaphragmatic lymphatic channels or through defects in the diaphragm
transdiaphragmatic channels are larger on what side
right
effusions caused by acute or chronic pancreatitis are most often on what side
left; because of the proximity of the pancreatic tail to the left hemidiaphragm
type of effusion associated with pancreatitis
exudative and may be bloody
high concentration of amylase in pleural fluid should suggest what etiology of effusion
pancreatitis, malignancy or esophageal perforation
subphrenic abscess, along with diaphragmatic paresis, basilar atelectasis and pleural effusion may be secondary to
complicated abdominal surgery or perforation of hollow viscus
pelvic and abdominal tumors that may produce PE
- ovarian fibroma (Meigs syndrome),
- pancreatic,
- lymphoma,
- uterine leiomyomas
type of effusion in Meigs syndrome
transudative; resolves after removal of pelvic tumor
pleural collection containing triglycerides in the form of chylomicrons
chylothorax
chylothorax happens due to
rupture of thoracic duct contents secondary to malignancy, iatrogenic trauma or TB
thoracic duct originates from
cisterna chyli at the level of the first lumbar vertebra and ascends along the right paravertebral space, entering the thorax via the aortic hiatus
thoracic duct inserts at what hiatus
aortic hiatus
the thoracic duct ascends and crosses from right to left at the level of
T6 alongside the upper esophagus
disruption of the upper thoracic duct caused by direct trauma or obstruction produces effusion on what side
left
lower intrathoracic duct rupture produces effusion at what side
right
triglyceride levels exceeding 110mg/dL in pleural fluid represents
chylothorax
effusion in pulmonary embolism may be associated with elevation of the ipsilateral diaphragm and peripheral wedge-shaped opacities called
Hamptom hump
PE characteristics from pulmonary embolism
typically small, unilateral, serosanguineous exudate
drugs that may cause PE
Pleural inflammation •Methysergide Lupus-like syndrome (HIPP) •Phenytoin •Isoniazid •Hydralazine •Procainamide Nitrofurantoin – a pleuropulmonary disease with eosinophilia
characteristics of PE that has a moderate to high risk for poor outcome
large, loculated collections with positive gram stains or cultures and pH <7.20
treatment options for parapneumonic effusions
- intrapleural fibrinolytic therapy using tPA with concomitant DNAse,
- video-assisted thoracoscopic surgery or thoracotomy with decortication
malignant PE most often require what treatment
closed drainage and pleural sclerosis with talc
True or false: talc pleurodesis can cause FDG-PET positive nodularity that is a source of false-negative PET evaluations
true
postcardiac injury patients (Dressler syndrome) that developed effusion are treated by
NSAIDs
communication between the lung and the pleural space that often originates from a peripheral airway
bronchopleural fistula
often develops from dehiscence of a bronchial stump following lobectomy or pneumonectomy, or as a result of a necrotizing pulmonary infection
bronchopleural fistulas
etiology of primary spontaneous pneumothorax
no identifiable etiology
presents as crescentic nondependent lucency that parallels the chest wall and displaces the visceral pleural line centrally
pneumothorax
signs of pneumothorax on supine radiography include
Non-dependently and indiscernible increased lucency over the lower thorax and upper abdomen Hyper lucent upper abdomen Deep sulcus sign Double diaphragm sign Epicardial fat pad sign Unusually sharp heart border
oUpright radiography
Non-dependent lucency that parallel the chest wall and displaces the visceral pleural line medially
most common cause of pneumothorax
trauma
2 mechanisms of pneumothorax formation from blunt chest trauma
acute increase in intrathoracic pressure results in extra alveolar interstitial air because of alveolar disruption, which tracks peripherally and ruptures into the pleural space;
laceration of the tracheobronchial tree
primary spontaneous pneumothorax most often occurs in
young or middle aged men, propensity for tall, thin individuals
treatment for primary spontaneous pneumothorax
closed tube drainage, thoracoscopic bullectomy
most common etiology for secondary spontaneous pneumothorax
COPD
most common malignancies to produce pneumothorax
sarcomas
osteogenic sarcoma, lymphoma, germ cell malignancies
most common connective tissue disease producing pneumothorax
marfan syndrome; usually from rupture of apical bullae
rare type of recurrent pneumothorax that occurs with menstruation
catamenial pneumothorax
age of patients affected by catamenial pneumothorax
fourth decade
cause of catamenial pneumothorax
cyclical necrosis of pleural endometrial implants which creates an air leak between the lung and pleura
side of predilection of pneumothorax in catamenial pneumothorax
right
true or false: catamenial pneumothorax resolves spontaneously
true
catamenial pneumothorax is managed by
inducing amenorrhea
critical condition that most often results from iatrogenic trauma in mechanically ventilated patients
tension pneumothorax
tension pneumothorax results from
check-valve pleural defect that allows air to enter but not exit the pleural space
4 clinical presentation of tension pneumothorax
tachypnea,
tachycardia,
cyanosis,
hypotension
true or false: contralateral mediastinal shift from pneumothorax does not invariably indicate tension, since an imbalance in the degree of negative intrapleural pressure can produce shift in the absence of tension. therefore, tension pneumothorax remains a clinical diagnosis
true
it is the end result of peripheral parenchymal and pleural inflammatory disease with pneumonia as the most common cause
localized pleural thickening
common cause of pleural calcifications
prior hemothorax or empyema (TB), pleural fibrosis