Platelet Disorders

Question 1

Cause of immune thrombocytopenia purpura

Answer 1

IgG Abs coat platelets and cause damage

Question 2

Treatment for ITP

Answer 2

Corticosteroids
IVIg
splenectomy (curative in 80%)
Platelet Transfusion

Question 3

Path of Thrombotic Thrombocytopenia Purpura

Answer 3

Platelets consumed by unknown cause. Hyaline micro thrombi occlude small vessels of organs and cause mechanical damage to RBCs

Question 4

What is Tx for TTP

Answer 4

Plasmaheresis
Corticosteriods
Splenectomy
NOT platelet transfusion (they are clumping and causing the problem to begin with)

Question 5

Describe the two types of Heparin Induced Thrombocytopenia

Answer 5

Type 1: heparin causes platelet aggregation within 48hrs of starting the drug

Type 2: 3 to 12 days after starting heparin antibodies form against it AND the platelets causing destruction of the platelets