Coagulopathies

Question 1

Genetics of vWD

Answer 1

Autosomal Dominant

Question 2

Why does vWD affect the coagulation cascade?

Answer 2

vW factor stabilizes and transports Factor VIII of the intrinsic pathway so vWD also CAN but does not have to show increased PTT

Question 3

Main treatment for vWD

Answer 3

desmopressin (induces secretion of vWF)

Question 4

Most common site of hemarthrosis in Hemophilia A

Answer 4

Knees

Question 5

Treatment for hemathrosis in Hemo A

Answer 5

codeine for pain

Question 6

Why is desmopressin a treatment for Hemo A

Answer 6

it stimulates vWF production which stabilizes any Factor VIII that is made

Question 7

Most common patients to get DIC

Answer 7

ICU patients

but also common in OB, malignancy, shock, trauma

Question 8

Most common cause of the two major complications of DIC

Answer 8

1. Hemorrhage: intracranial hemorrhage is most common

2. Thromboembolism: PE, acute renal failure, bowel infarction

Question 9

Treatment for DIC

Answer 9

Treat underlying condition
FFP for clotting factors
platelets
Low dose heparin to inhibit clotting