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Hem/Onc > Platelet and Coagulation Inhibition Pharm > Flashcards

Platelet and Coagulation Inhibition Pharm Flashcards

1
Q

Warfarin

A

Vitamin K epoxide reductase inhibitor

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2
Q

Unfractionated heparin

A

Enhances antithrombin III mediated inhibition of thrombin and FXa

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3
Q

Enoxaparin, Dalteparin

A

LMWH (heparin, but more specific for FXa and less for thromin

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4
Q

Fondaparinux

A

Synthetic Pentasaccharide, bind and selectively inhibit FXa

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5
Q

Rivaroxaban, Apixaban

A

Direct factor Xa inhibitors

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6
Q

Dabigatran

A

Direct thrombin inhibitor

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7
Q

Argatroban

A

Direct thrombin inhibitor

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8
Q

Lepirudin

A

Direct thrombin inhibitor

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9
Q

Aspirin

A

Irreversible COX inhibitor (COX1>COX2) leads to less TXA2

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10
Q

Clopidogrel, Prasugrel, Ticlopidine

A

Irreversible P2Y12 (ADP-R) Blockers leading to less expression of GPIIb/IIIa receptor

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11
Q

Ticagrelor

A

Reversible P2Y12 inhibitor

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12
Q

Vorapaxar

A

Protease-activated receptor inhibitor (PAR-1) this is the thrombin receptor

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13
Q

Dypyridamole

A

Phosphodiesterase inhibitors leading to an increase in cAMP

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14
Q

Reversal Agent for Heparin

A

Protamine Sulfate

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15
Q

Altepase

A

fibrin specific fibrinolytic

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16
Q

Reteplase

A

Truncated t-PA, less fibrin specific but cheaper

17
Q

Tenecteplase

A

Mutated t-PA, more specific

18
Q

Streptokinase

A

Streptococci derived substance that binds plasminogen and forms an active enzyme complex without proteolytically cleaving plasminogen

19
Q

Reversal agent for fibrinolytics?

A

epsilon- aminocaproic acid

20
Q

Which crosses placenta and is teratogenic- heparin or warfarin?

A

Warfarin

21
Q

How much of warfarin is bound in plasma?

A

99%

22
Q

Administered for HIT?

A

Argatroban and Lepierudin

23
Q

Can cause TTP?

A

Clopidogrel

24
Q

Can cause SOB?

A

Ticagrelor

25
Q

Can cause Hypotension

A

Abciximab

26
Q

Aciximab, Eptifibatide, tirofiban

A

Glycoprotein IIb/IIIa inhibitors

Hem/Onc (3 decks)

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