Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Hem/Onc > Platelet and Coagulation Inhibition Pharm > Flashcards

Platelet and Coagulation Inhibition Pharm Flashcards

1
Q

Warfarin

A

Vitamin K epoxide reductase inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Unfractionated heparin

A

Enhances antithrombin III mediated inhibition of thrombin and FXa

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Enoxaparin, Dalteparin

A

LMWH (heparin, but more specific for FXa and less for thromin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Fondaparinux

A

Synthetic Pentasaccharide, bind and selectively inhibit FXa

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Rivaroxaban, Apixaban

A

Direct factor Xa inhibitors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Dabigatran

A

Direct thrombin inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Argatroban

A

Direct thrombin inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Lepirudin

A

Direct thrombin inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Aspirin

A

Irreversible COX inhibitor (COX1>COX2) leads to less TXA2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Clopidogrel, Prasugrel, Ticlopidine

A

Irreversible P2Y12 (ADP-R) Blockers leading to less expression of GPIIb/IIIa receptor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Ticagrelor

A

Reversible P2Y12 inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Vorapaxar

A

Protease-activated receptor inhibitor (PAR-1) this is the thrombin receptor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Dypyridamole

A

Phosphodiesterase inhibitors leading to an increase in cAMP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Reversal Agent for Heparin

A

Protamine Sulfate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Altepase

A

fibrin specific fibrinolytic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Reteplase

A

Truncated t-PA, less fibrin specific but cheaper

17
Q

Tenecteplase

A

Mutated t-PA, more specific

18
Q

Streptokinase

A

Streptococci derived substance that binds plasminogen and forms an active enzyme complex without proteolytically cleaving plasminogen

19
Q

Reversal agent for fibrinolytics?

A

epsilon- aminocaproic acid

20
Q

Which crosses placenta and is teratogenic- heparin or warfarin?

21
Q

How much of warfarin is bound in plasma?

22
Q

Administered for HIT?

A

Argatroban and Lepierudin

23
Q

Can cause TTP?

A

Clopidogrel

24
Q

Can cause SOB?

A

Ticagrelor

25
Q

Can cause Hypotension

26
Q

Aciximab, Eptifibatide, tirofiban

A

Glycoprotein IIb/IIIa inhibitors

Hem/Onc (3 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions