Chemo Flashcards
Name the M-Phase Drugs
Vincristine, Vinblastine, Taxols
Name the G2-Phase Drugs
Etoposide, Bleomycin
Key side effect of anthracyclines?***
Cardiotoxicity–>CHF
SE of asparaginase
Pancreatitis, coagulopathy
SE of Bleomycin
Pulmonary Fibrosis
SE of Cisplatin***
N/V, Ototoxicity, Nephrotoxicity
SE of Cyclophosphamide/ ifosfamide***
hemorrhagic cystitis
Secondary AML: long interval (c5, c7 abnormalities)
SE of cytosine arabinoside (Ara C)
cerebellar toxicity, hemorrhagic conjunctivitis
SE of dactinomycin
hepatic vaso-occlusive disease
SE of Etoposide
anaphylaxis Secondary AML (short interval, 11q23)
Which two chemo agents can cause secondary AML? What is the difference?***
1) Etoposide: short interval, c11q23
2) Cyclophosphamide/ifosfamide: long interval, c5, c7
SE of irinotecan
Severe diarrhea
SE of nitrosoureas
delayed myelosuppression
SE of rituximab
HepB reactivation, PML
SE of Taxols
Peripheral neuropathy, HSR
SE of vincristine
neuropathy
Antidote for methotrexate ***
Folinic acid (Leucovorin)
Antidote for 5-FU
Thymidine
Toxicity modifier for cyclophosphamide/ifosfamide ***
MESNA (required with ifosfamide)
Toxicity modifier for anthracyclines ***
dexrazoxane
Toxicity modifier for cytosine arabinoside
dexamethasone eye drops
Toxicity modifier for taxols
H1 and H2 blockers
Toxicity modifier for irinotecan
cefpodoxine preRx, atropine, imodium
Which four agents are prodrugs?
Cyclophosphamide, Ifosfamide, Temozolamide, Irinotecan
