Platelet and coagulation disorders Flashcards
1
Q
In which sex does thrombotic thrombocytopenic purpura predominate?
A
Female
2
Q
What is the cause of thrombocytopenic purpura predominate?
A
ADAMTS13 deficiency/autoantibodies
Acquired (95%)
Congenital (5%)
3
Q
Name risk factors for thrombocytopenic purpura predominate
A
Pregnancy SLE HIV Cancer Infections
4
Q
What is the pentad of clinical features seen in thrombocytopenic purpura predominate?
A
- Fever
- Neurological symptoms
- stroke
- focal defects
- headache - Thrombocytopenia
- purpura
- mucosal bleeding
- prolonged bleeding - Microangiopathic hemolytic anemia
- fatigue
- pallor
- jaundice - Impaired renal function
- haematuria
- proteinuria
5
Q
How do you diagnose thrombotic thrombocytopenic purpura predominate?
A
Bloods
- ↓ Platelets
- ↓ Hemoglobin
- ↑ Reticulocytes
- ↓ Haptoglobin
- normal PT
- normal aPTT
- normal D dimers
- ↑ LDH (hemolysis)
- ↑ indirect bilirubin (hemolysis)
- ↑ BUN (impaired kidney function)
- ↑ creatinine (impaired kidney function)
6
Q
How do you treat thrombotic thrombocytopenic purpura?
A
Electrolytes Blood transfusion Plasma exchange therapy Glucocorticoids Rituximab
7
Q
Name complications of thrombotic thrombocytopenic purpura
A
Stroke
Hemorrhagic colitis
Chronic kidney disease
LFT derangements
