Plastic Surgery Flashcards
What are the 3 stages of wound healing and when do they BEGIN?
- Coagulation stage - 10-15 min after wound formation
- Inflammatory stage - first 24 hrs
- Initial proliferation - days 2-3
What happens during the coagulation stage?
- vasoconstriction, clotting cascade in first 10-15 min
- vasodilation 2/2 histamine, complement, kinins, PGs
What happens during the inflammatory stage? (early, late)
- Early - platelets release chemotactants, vasogenic amines, GFs. PMNs attracted to site.
- Late - blood monocytes/macrofages infiltrate at 48-72 hrs, replace PMNs
- Epithelialization begins by POD 2, Begins at wound edge, enlarges, flattens, migrates over wounds, dissolves clots and scabs
By 6 wks after wound formation ___% of strength is gained
60
What happens during the initial proliferation phase of wound healing? (2)
- collagen formation
- macrophages replaced by fibroblasts
When does the proliferative phase of wound healing occur and what 3 main things happen during this time?
- days 4-24
- Angiogenesis, fibroplasia, epithelialization continues
At what time do fibroblasts become the predominate cells during wound healing?
- Day 7
What is the role of the fibroblasts in wound healing (what do they produce) (3)?
- make fibronectins
- glycosaminoglycans
- Collagen (initially type III)
3 weeks after a wound the wound will be in the _____ stage
maturation/remodeling
What happens during the maturation/remodeling stage? (3)
- collagen III –> I (stronger)
- tensile strength increases due to collagen crosslinking (but never reaches full, max 80%)
- cells are myofibroblasts
How long does it take for scars to form?
up to 1 year
How do you treat abrasions?
scrub brush or dermabrasion to avoid traumatic tattoos
How do you treat contusions?
evacuate hematomas - cold early on, heat later
How do you treat lacerations?
debridement and suture
How do you treat punctures?
evaluate for underlying damage, debridement, and primary or secondary intention
What 3 things should occur during debridements?
- actual bleeding should be seen
- dress the wound in wet to drys - needs to be continuously moist
- tetanus shot, culture wound, abx
debridement must occur constantly for _______ wounds
chronically infected
____ will determine the extent of infection
x-ray
you must assess vascular supply of wounds with _____ (3)
- Doppler, angiogram, pulses
for wound healing you must have ____ control
glycemic
What is the role of hyperbaric O2 in wound healing?
- O2 gradient between the center of the wound and edge initiates wound healing
- helps neutrophils kill bacteria, aids in collagen synthesis and angiogenesis
What is healing w/2nd intention used for?
small wounds or if patient is too ill for the operation
What is a potential AE from healing w/2nd intention.
Marjolin’s ulcer (SCC)
What is primary intention closure and what is it used for?
- direct reapposition of wound skin edge
- used for low velocity
With primary intention closure look for signs of _____ that includes ______
- excessive skin tension
- pallor, loss of distal pulses, compartment pressures >30
What is secondary intention wound closure?
- wound left open to heal spontaneously via inflammatory phase
What happens during secondary intention wound healing?
- wound contracts and margins meet and re-epithelialize
What is tertiary intention closure?
Delayed wound closure and healing is intentionally interrupted
Primary contracture definition
contracture of the dermis due to elastin (the more dermis the more contracture). Full thickness skin grafts (FTSG) have the most primary contracture
Secondary contracture definition
contraction of the healed scar d/t myofibroblast activity. The thinner the graft the greater the contracture, as with split thickness skin graft (STSG) because the dermis layer inhibits contracture and STSG has less of the dermis
What is a split thickness graft (STSG)?
- epidermis + part of the dermis
What kind of split thickness graft has a better chance of taking?
thin grafts
Disadvantages to split-thickness grafts?
- shrinks in size as it heals since less dermis means its less affective at inhibiting secondary contraction
- less cosmetic d/t hyperpigmentation - DO NOT use on the hands or face
- more chance of trauma
What is a full thickness graft (FTSG)
- epidermis + dermis