plasma proteins and blood clotting

Question 1

plasma proteins are synthesized in the

Answer 1

liver or reticuloendothelial cells

Question 2

major groups of plasma proteins are

Answer 2

albumin
alpha 1
alpha 2
beta
gamma globulins

Question 3

functions of plasma proteins

Answer 3

transport molecules
colloid osmotic pressure
iron and heme metabolism
protease inhibitors
coagulation
immune response

Question 4

function of plasma proteins: transport molecules

Answer 4

albumin transports bilirubin and fatty acids
transferrin transports iron
ceruloplasmin transports copper
lipoproteins transport lipids

Question 5

function of plasma proteins: iron and heme metabolism

Answer 5

hemopexin bind heme

haptoglobin binds hemoglobin

Question 6

function of plasma proteins: protease inhibitors

Answer 6

alpha 1 antitrypsin inhibits elastase activity

causes COPD aka emphysema

Question 7

function of plasma proteins: coagulation

Answer 7

converts fibrinogen (factor I) to fibrin catalyzed by thrombin

Question 8

intrinsic pathway
Factor IV:
Factor X:
Factor XIIIa :

Answer 8

Factor IV: calcium
Factor X: activated by intrinsic and extrinsic pathway and leads to final common pathway
Factor XIIIa : converts fibrin to cross linked fibrin clot

Question 9

activated clotting factors are?

Answer 9

serine protease

Question 10

final common pathway

Answer 10

prothrombin converted to thrombin catalyzed by 10a

thrombin makes fibrinogen to fibrin which makes cross linked fibrin clot by factor XIIIa

Question 11

hemophilia A

Answer 11

caused by deficiency of factor VIII

Question 12

hemophilia B

Answer 12

from deficiency of Factor IX

Question 13

Factor V Leiden mutation

Answer 13

increases body’s blood clotting process by resistance to inactivation by protein C which regulates blood clots

Question 14

von willebrand factor

Answer 14

decreases blood clotting activity by binding factor VIII to prevent its degradation

Question 15

transferrin

Answer 15

transports iron

Question 16

heparin (anticoagulant) prevents clotting by?

Answer 16

enhancing action of antithrombin III

Question 17

anticoagulants

Answer 17

compounds that bind calcium

Question 18

dicoumarol and warfarin

Answer 18

inhibit carboxylation of glutamate to give g-carboxyglutamyl residues in prothrombin that bind calcium