Plasma Concentration Profile

Question 1

What is peak plasma concentration ?

Answer 1

Maximum drug level obtained with the dose administered

Question 2

What is the most important parameter in evaluating bioavailability of drugs ?

Answer 2

Area under curve

Question 3

What is the therapeutic range of a drug?

Answer 3

The concentration between MEC and MSC

Question 4

Formula to calculate elimination half life of a drug?

Answer 4

0.693/Kel

Where Kel is the elimination rate constant

Question 5

3 uses of elimination half life ?

Answer 5

1. To estimate elimination time
2. To estimate rate of accumulation of drug in the body incase of multiple dose
3. To estimate the relationship between loading dose and maintenance dose

Question 6

What happen in zero order kinetics?

Answer 6

Rate of elimination remain constant and does not change with change in plasma concentration of the drug

Question 7

What happen to clearance of a drug if the concentration increases in zero order Kinetics?

Answer 7

Clearance decreases

Question 8

What happen to clearance of a drug when concentration increase in first order kinetics ?

Answer 8

Clearance remains constant

Question 9

What happens in first order kinetics ?

Answer 9

Rate of elimination of a drug is directly proportional to plasma concentration of drug

Question 10

What happens in a steady state of first Order kinetics?

Answer 10

Rate of administration is equal to rate of elimination