Drug Excreation Flashcards
1
Q
Mention 5 principal organ of excretion?
A
Kidney
Bike
Lungs
Mammary gland
Skin
2
Q
5 factors affecting renal excretion ?
A
- Physio chemical properties of the drug
- Biological factors
- Glomerular filtrate rate
- Degree of protein binding
- Drug interactions
3
Q
Two factors that affect glomerular filtration of drugs ?
A
Plasma protein binding and renal blood flow
4
Q
What is the PH of urine ?
A
4.5 - 7.5
5
Q
What is the effect of urine flow on tubular reabsorption and excretion ?
A
Increase urine flow rate decreases reabsorption and reduces excretion
6
Q
What is drug clearance ?
A
Fixed volume of fluid cleared of the drug per unit time
7
Q
How does blood flow affect drug clearance ?
A
Cl=KeVd
Volume of distribution and elimination rate constant are both affected by blood flow
