Plasma Composition & Red Cell Metabolism-Goueli

Question 1

What shifts the oxygen saturation curve to the RIGHT?

Answer 1

H+ increase (decreased pH)
CO2 increases
Temp increases

2,3 BPG increase

**MORE O2 delivered

Question 2

What shifts the oxygen saturation curve to the LEFT?

Answer 2

H+ decreases (increased pH)
CO2 decreases
Temp decreases

2,3 BPG decrease

*** LESS O2 delivered

Question 3

Hereditary spherocytosis cause by?

Answer 3

-Defect in RBC cytoskeleton proteins

Question 4

How is B6PG deficiency transmitted?

Answer 4

X linked!

Question 5

What happens in cirrhosis and why do people get ascites?

Answer 5

Cirrhosis –> Damage the liver –> can’t make as many plasma proteins –> decreased albumin –>

–> decreased plasma proteins –> decreased oncotic pressure –> lose the draw of fluid from tissues into vessels

–> Ascites (build-up of fluid in the space between the lining of the abdomen and abdominal organs)

Question 6

Acquired Methemoglobinemia

Answer 6

Causes oxidation of Fe2+ —> Fe3+

From giving BENZOCAINE, lidocaine, dapsone.
From ingestion of oxidates: nitrites, quinones, anilines, and sulfonamides

Tx: reducing agents (ascorbic acid or methylene blue)