Plasma cell dyscrasias

Question 1

Plasma cell myeloma (multiple myeloma)

Answer 1

Older males

Bone pain, pathologic fractures, anaemia, recurrent infections, renal failure

Also hyperviscosity, hypercalcaemia, spinal cord compression

Monoclonal serum protein - IgG, igA, light chain, IgD

Non-secretary myeloma 1% of cases

BJ protein in 80%

Question 2

Plasma cell myeloma immuno

Answer 2

CD138, CD38 (not specific) (plasma cell markers)