Plasma cell dyscrasias

Question 1

plasma cells?

Answer 1

terminally differentiated B cells. clock face chromatin.

Question 2

M protein?

Answer 2

abnormal/excess Ig fragment or LC due to abnormal clonal proliferation of plasma cells. in serum and or urine

Question 3

bence jones proteins?

Answer 3

free light chains in urine. if gglomerular damage.

Question 4

how to ID m protein? found when?

Answer 4

electrophoresis: high peak at right edge. in monoclonal gammopathies.

Question 5

multiple myeloma?

Answer 5

M, AA, 50-70. 3 criteria: 1 clonal plasma cells (BM, plasmacytoma); 2 M protein in serum and or urine, or bence jones; 3 end organ damage. cause of death often infection.

Question 6

MM end organ damage types?

Answer 6

hypercalcemia (lytic bone lesions), renal insufficiency, anemia (rouleaux), bone disease.

Question 7

plasmacytomas?

Answer 7

localized growth of monoclonal plasma cells. none in BM. 2 kinds: extramedullary plasmacytoma and solitary plasmacytoma of bone

Question 8

lymphoplasmacytic lymphoma?

Answer 8

lymphoma with plasmacytic differentiation. IgM paraprotine. Waldenstrom’s macroglobulinemia.

Question 9

Waldenstrom’s macroglobulinemia?

Answer 9

visual/neurologic problems due to occlusion. cryoglobulinemia: rayneaud’s, bleeding

Question 10

monoclonal gammopathy of undetermined significance?

Answer 10

3 criteria: < 3 g/dL M protein in serum, < 10% clonal plasma cells in BM, no myeloma related end organ damage
precursor to MM in 25%

Question 11

amyloidosis?

Answer 11

deposition of amyloid (extracellular, misfolded protein). congo red positive. primary amyloidosis seen in 5-10% MM, other plasma cell disorders