Benign Leukocyte Disorders Flashcards
1
Q
Leukemoid reaction?
A
exaggerated response to infection. abs leukocytes > 50,000
2
Q
leukoertythroblastic rection?
A
immature BM cells in PB. due to BM infiltrative dz, severe BM stress
3
Q
neutrophilia?
A
> 7000; infection, inflammation, drugs. toxic change
4
Q
neutropenia?
A
< 1500; chemo, immune destruction, septic shock. INCREASED SUSCEPTIBILITY TO INFECTION
5
Q
eosinophilia?
A
>
- neoplasms, asthma, AIN, atopy, addison’s, CVDs, parasites
6
Q
basophilia?
A
>
- chronic myeloproliferative neoplasm- CML, CKD.
7
Q
histiocytic conditions?
A
langerhans cell histiocytosis, hemophagocytic lymphohystiocytosis
8
Q
langerhans cell hystiocytosis
A
CD1a, langerin. birbeck granules. BRAF mutation
9
Q
HLH
A
primary HLH: defects in perforin.
secondary HLH: EBV, lymphomas.
very high ferritin. hypertrigliceridemia, hypofibrinogenemia, hemophagocytosis
