Plant-derived natural products in clinical trials, Generic name & Number of recruiting clinical trialsb: indications (potential mechanism of action)

Question 1

β-Lapachone

Answer 1

1 trial: Solid tumors (E2F1 pathway activator)

Question 2

Curcumin

Answer 2

26 trials: Cognitive impairment, different types of cancer (NF-κB inhibition)

Question 3

Epigallocatechin-3-O-gallate

Answer 3

14 trials: Epstein-Barr virus reactivation in remission patients with nasopharyngeal carcinoma, multiple system atrophy, Alzheimer’s disease (cell growth arrest and apoptosis induction)

Question 4

Genistein

Answer 4

5 trials: Colon cancer, rectal cancer, colorectal cancer (protein-tyrosine kinase inhibitor, antioxidant)

Question 5

Gossypol

Answer 5

2 trials: B-cell chronic lymphocytic leukemia, refractory chronic lymphocytic leukemia (Bcl-2 inhibitor)

Question 6

Picropodophyllotoxin

Answer 6

Picropodophyllotoxin (tubulin binding/IGF-1R Inhibitor)

Question 7

Quercetin

Answer 7

9 trials: Chronic obstructive pulmonary disease, Fanconi anemia (NF-κB inhibition)

Question 8

Resveratrol

Answer 8

22 trials: Pre-diabetes, vascular system injuries, lipid metabolism disorders (including non-alcoholic fatty liver disease) (NF-κB inhibition)