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Micro Post Q3 > Plague, Tularemia, Brucellosis > Flashcards

Plague, Tularemia, Brucellosis Flashcards

1
Q

What organism causes bubonic and pneumonic plague?

A

Yersinia Pestis

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2
Q

Describe the shape of Y. Pestis

A

Large coccobacillary Gram Negative

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3
Q

Does Y. Pestis ferment lactose?

A

Nope

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4
Q

Describe the steps in transmission of bubonic plague (4)

A
  1. Flea gets Y. Pestis from blood meal.
  2. Y. Pestis multiplies and obstructs foregut.
  3. Next meal the flea vomits bacteria onto bite site.
  4. Orgaisms enter lymphatics and cause regional adenitis.
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5
Q

How is pneumonic plague transmitted?

A

respiratory droplets

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6
Q

How do humans get urban plague?

A

Rats die off and the fleas seek new hosts.

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7
Q

Can urban plague cause bubonic and pneumonic?

A

YES!

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8
Q

What are the 3 types of transmission of rural plague in the US?

A

Flea bite, hand contact with infected mammal, contact with domestic pets.

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9
Q

What is the main virulence factor in Y. Pestis?

A

Capsule (F1 Antigen)

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10
Q

What are the V and W antigens used for in Y. Pestis?

A

Survival within macrophages.

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11
Q

Is Y. Pestis an Intracellular or extracellular pathogen?

A

Both!

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12
Q

What types of toxin(s) does Y. Pestis have?

A

LPS and exotoxin.

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13
Q

What type of Y. Pestis infection presents with: fever, malaise, and painful lymphadenopathy?

A

Bubonic plague

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14
Q

What type of Y. Pestis infection presents with: fever, cough, shortness of breath?

A

Pneumonic plague.

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15
Q

What type of Y. Pestis infection presents with: no bubo, widespread dissemination via blood?

A

Septicemic plague

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16
Q

Name 2 complications of Y. Pestis infection.

A

Skin hemhorrages via DIC (“black death”)

Plague meningitis

17
Q

Is there a vaccine? Who uses it?

A

Inactivated vaccine used by US troops in Vietnam

18
Q

Name 3 methods to diagnose Y. Pestis infection.

A
  1. Bubo aspirate
  2. Blood culture
  3. Serology - anti F1 antibodies.
19
Q

How to treat Y. Pestis infection

A

10 days of tetracycline (or streptomycin/chloramphenicol

Micro Post Q3 (4 decks)

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