Placidity Flashcards

1
Q

Draw out the basic anatomy of the neuron

A

where is the:
cell membrane
dendrites
cell body
axons
nodes of ranvier
myelin sheath
oligodendrocytes
synapse

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2
Q

where is the axon hitting on the cells

A

axo-dedritic
axo-somatic
axo-axonic
dendron-denritic

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3
Q

what are the glia and what are the different types of glia

A

ependymal cells
-lining of the ventricles (CSF)
oligodendrocytes
-creates meylin sheath
microglia
-policeman
-clean up the debris
Astrocytes
- scaffolding for the brain
-most abundant

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4
Q

what are the different types of neurons

A

pyramidal
purkinje
granule
spindle
interneuron

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5
Q

what is a pyramidal neuronal cell

A

Found in the cortex – usually associated with initiation of movement and thought

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6
Q

what is a purkinje neuronal cell

A

Found in the cerebellum – multiple feedbacks for precise movements

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7
Q

what is a granule neuronal cell

A

found throughout the brain, cerebellum, olfactory, and hippocampus

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8
Q

what is a spindle neuronal cell?

A

Connections to different parts of the brain
*May be involved in some psych disorders

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9
Q

what is an interneuron neuronal cell?

A

connections between to help regulation normally inhibitory

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10
Q

What does plasticity mean?

A

the ability for neurons to adapt and perfect the flow of information with the inflow or outflow

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11
Q

what are the two main points of plasticity?

A

arborization
de-arborization

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12
Q

what is arborization when it comes to plasticity

A

The process in which connections are made including dentrites, axons, and/or telodendrites. (synaptogenesis)

Can enhance a skill/memory

Over-arborization can lead to problems including increased reflexes, pain, or the inability to process information

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13
Q

how is arborization performed?

A

Increase in the amount of neurotransmitters
Increased connections from the pre-synaptic neuron
Increased connections from the post-synaptic neuron
BOTH

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14
Q

what is the ultimate goal of arborization

A

allow better ease of depolarization

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15
Q

what is dearborization when it comes to plasticity

A

the loss of connections
also known as pruning
occurs for a few reasons:
- natural development
-loss of represented structures
-loss of a skill
- brain insult or infraction

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16
Q

what is the time line of plasticity

A

from 36 week gestation to 2 years there is synapse formation

from 4 to 6 years there is synapse pruning occurring

17
Q

what are the four types of learning?

A

hebbian learning
retrograde signaling
mirror neuron signaling
anti-hebbian learning

18
Q

what is hebbian learning

A

neurons will fire together, wire together
presynaptic neuron strengthens connections

19
Q

what is retrograde signaling

A

neurons surrounding the pre-synaptic neuron get stronger with the post synaptic neurons
increased neurotransmitters or nitrous oxide

20
Q

what is mirror neuron signaling

A

neurons that fire during active and observation of activity
increase connectivity and lateralization

21
Q

what is the anti hebbian style of learning

A

-the post synaptic neuron mediates the connection
-mediates the response when two types of inputs may enter the cell
- thought to occur in the cerebellum

22
Q

what are the principles of neuroplasty

A

-use it or lose it
-specificity of practice
-intensity matters
-time matters
-transference
-use it and improve it
-repitions or dosage matters
-salience matters
-age matters
-interference

23
Q

explain the concept of use it or lose it to me?

A

Plasticity is always occurring
The brain will take over different regions if lost or unused.
Is the old phrase “Pick it back up like riding a bike true”?
Time is key
In primate experiments:
A digit was amputated
The brain lost representation
The brain grew the surrounding representation

24
Q

explain the concept of use it and improve it to me

A

the use of a skill improves the acquisition of the task
certain types of settings or specific circumstances can increase the acquisition of skills

25
explain the concept of specificity of practice/transference
Training is usually task specific It’s very hard to improve one thing and it carry over to another skill UNLESS the skills are linked Complex may improve simple Like training strengthens like Strengthen one limb may help the other Performing task and watching may help (mirror neurons)
26
explain the concept of repetitions or dosage matters
Dr. Lang (Wash U. St. Louis) Dosage is extremely important ~1,000-10,000 repetitions to relearn and master a skill Under-dosing patient’s is a systemic problem How do we get around this?
27
explain the concept of intensity matters
Can be identified as: Power Time to completion Obstacle avoidance Increased speed of movement Target distance Variability of support
28
explain the concept of time matters
Usually the easiest time to affect change after a neurological insult, <6 months Too early can cause problems because the person needs to start to heal However, people can still regain tasks years after insult
29
explain the concept of salience matters
One of the most important parts Person must be engaged in the activity If you find something the person likes, they are more likely to attend to the task and continue with it Increases belief in the themselves AND you
30
explain the concept of why age matters
Younger tends to be easier Healthy older adults can learn to Declining in cognition or extreme advanced age may play a role (but not always)
31
explain the concept of interference
Some plasticity may interact and impede other plasticity Learning a secondary task may initial impede performance on primary task
32
what are other factors effecting plasticity
Experience with tasks Mood and willingness to engage Sleep or lack of Fitness Pharmaceuticals Underlying disease or comorbidities