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OB GYN > Placental Hormones > Flashcards

Placental Hormones Flashcards

0
Q

Major site of steroid and protein production

A

Syncitiotrophoblast

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1
Q

Septeroidgenesis in pregnancy is composed of 3 compartments:

A

Fetal
Placental
Maternal

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2
Q

_____ utilized LDL cholesterol from maternal plasma for progesterone biosynthesis

A

Human syncitiotrophoblast

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3
Q

What are the placental protein hormones:

A 
hPL
HCG
ACTH
HGH-v
PTH-rP
Calcitonin
Relaxin
Inhibin
Activins
ANP
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4
Q

Hypothalamic like releasing and inhibitory hormones

A 
TRH
GnRH
CRH
Somatostatin
GHRH
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5
Q

The hormone produced by the fetal compartment

A

Alpha fetoprotein

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6
Q

The hormone produced by the maternal compartment

A

Prolactins
Relaxins
Decidual proteins

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7
Q

Glycoprotein that has same biological activity as LH

A

Human chorionic gonadotropin

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8
Q

HCG is produced by:

A

Placenta
Fetal kidney
Malignant tumors

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9
Q

HCG has the highest CHO content of nay human hormone by __ %

A

30%

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10
Q

Plasma half life of HCG

A

36 hours

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11
Q

Plasma levels of free beta subunits increase steadily until the __ weeks of pregnancy and then plateau till the end of pregnancy

A

36th

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12
Q

Rate of secretion of the complete hCG molecule is maximal at __ weeks of gestation

A

8-10 weeks

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13
Q

____ is produced by ___ that acts as a paracrine manner on syncitiotrophoblast to stimulate hCG production

A

Placental GnRH

Cytotrophoblast

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14
Q

Other agents that believe to influence HCG secretion in trophoblast:

A 
IL 6
Epidermal growth factor
cAMP
Activin +
Inhibin -
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15
Q

____ weeks HCG is expressed in both syncititiotrophoblast and cytotrophoblast

A

< 5 weeks

16
Q

HCG is almost exclusively produced by ___

A

Syncitiotrophoblast

17
Q

Intact hCG molecule is detectable in plasma of pregnant woman in about ___ days after the midcycle surge of LH that preceeds ovulation

A

7-9 day

18
Q

HCG enters maternal blood at the time of ___

A

Blastocyst implantation

19
Q

Blood levels of HCG increases rapidly, doubling every ____

A

2 days

20
Q

Between 60th and 80th days after the last menses peak levels reach about __

A

100,000 mIU/ml

21
Q

When HCG titers exceed ____, vaginal ultrasonography should identify an intrauterine gestation

A

1000-1500 IU/L

22
Q

In ____ weeks of gestation, maternal plasma levels begin to decline

A

10-12 weeks

23
Q

Causes an increase in HCG:

A 
Muktifetal pregnancy
Erythroblastosis fetalis
Fetal hemolytic anemia
GTD
Fetus with down syndrome
24
Q

Causes low levels of HCG:

A

Early pregnancy wastage (ectopic pregnancy)

25
Q

Biological functions of HCG:

A

☑️ Rescue and maintain functions of corpus luteum
☑️ Stimulation of fetal testicular testosterone secretion
☑️ Stimulation of maternal thyroid activity
☑️ Promotion of relaxin secretion by corpus luteum
☑️ Promote uterine vascular vasodilation and myometrial smooth muscle relaxation via LH-HCG receptors

OB GYN (11 decks)

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