PKPD Flashcards
1
Q
Predictive pharmacodynamic parameter for beta-lactam antibiotics
A
free drug time > MIC
2
Q
Predictive pharmacodynamic parameter for fluoroquinolone antibiotics
A
free AUC/MIC ratio
3
Q
Predictive pharmacodynamic parameter for aminoglycoside antibiotics
A
peak/MIC ratio
4
Q
Minimum T>MIC % of dosing interval for beta-lactams
A
Gram-negative: carbapenem 40%, penicillin 50%, cephalosporins 60%
Gram-positive: 40-50%
5
Q
Minimum AUC/MIC ratio for fluoroquinolones
A
Gram-negative: 100
Gram-positive: 30-40 (100?)
6
Q
What is the definition of tolerance?
A
MBC >= 32xMIC
7
Q
What is the definition of MBC?
A
lowest [drug] that results in >=99.9% reduction in original inoculum
