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PHARMACOLOGY > PK + PD > Flashcards

PK + PD Flashcards

1
Q

What processes are involved in drug disposition?

A

Distribution, Metabolism, Excretion

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2
Q

The relationship between the drug concentration and the pharmacologic response

A

Pharmacodynamics

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3
Q

Substance with affinity but without intrinsic activity

A

Antagonist

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4
Q

Substance that binds to a receptor but invokes an effect opposite to that of an agonist

A

Inverse agonist

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5
Q

Routes that give 100% bioavailability

A

Intravenous, Intra-arterial

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6
Q

What is in saliva that might interact with some drugs such as chewables and lozenges

A

Ptyalin, Mucin

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7
Q

The basis for absorption of acidic drugs in acidic medium

A

Henderson-Hasselbach equation

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8
Q

What form of drug predominates if acidic drugs are in a basic medium

A

Ionized form

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9
Q

What part of the small intestine is best for durg absorption

A

duodenum

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10
Q

What is the effect of increased volume of ingested material on the gastric emptying rate of drugs

A

initial increase, then decrease

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11
Q

What drug has an increased absorption when taken with a fatty meal

A

griseofulvin

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12
Q

How does the activation of the sympathetic nervous system affect the gastric emptying rate

A

Decrease = delayed absorption

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13
Q

Which part of the rectum absorbs drugs into the portal circulation first

A

Upper 1/3

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14
Q

What protein binds acidic drugs

A

Albumin

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15
Q

What happens to the volume of distribution when there is an increase in drug plasma concentration

A

decreased

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16
Q

What is the basis for the computation of the loading dose

A

Volume of distribution

17
Q

Formula of loading dose

A

Vd x target plasma conc

18
Q

After how many half lives does the drug reach a steady state concentration

A

3-4 half lives

19
Q

What drug is capable of autoinduction

A

Carbamazepine

20
Q

What type of alcoholism is a cyp450 inducer

A

Chronic alcoholism

21
Q

What fruit juice is an enzyme inhibitor

A

Grapefruit juice

22
Q

How does zero order kinetics appear on semilog paper

A

Nonlinear

23
Q

Is the drug elimination in first order kinetics dependent on drug concentration

A

Yes. Constant fraction eliminated every time

24
Q

Formula of drug clearance

A

Elimination rate/plasma conc
Vd x K

25
Q

What drug competes in the active tubular secretion of penicillin

A

Probenecid

26
Q

What component of the GIT contributes to the enterohepatic recycling of drugs

A

Microbial flora

27
Q

What drug undergoes intestinal excretion

A

Doxycycline

PHARMACOLOGY (3 decks)

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