PK + PD Flashcards
What processes are involved in drug disposition?
Distribution, Metabolism, Excretion
The relationship between the drug concentration and the pharmacologic response
Pharmacodynamics
Substance with affinity but without intrinsic activity
Antagonist
Substance that binds to a receptor but invokes an effect opposite to that of an agonist
Inverse agonist
Routes that give 100% bioavailability
Intravenous, Intra-arterial
What is in saliva that might interact with some drugs such as chewables and lozenges
Ptyalin, Mucin
The basis for absorption of acidic drugs in acidic medium
Henderson-Hasselbach equation
What form of drug predominates if acidic drugs are in a basic medium
Ionized form
What part of the small intestine is best for durg absorption
duodenum
What is the effect of increased volume of ingested material on the gastric emptying rate of drugs
initial increase, then decrease
What drug has an increased absorption when taken with a fatty meal
griseofulvin
How does the activation of the sympathetic nervous system affect the gastric emptying rate
Decrease = delayed absorption
Which part of the rectum absorbs drugs into the portal circulation first
Upper 1/3
What protein binds acidic drugs
Albumin
What happens to the volume of distribution when there is an increase in drug plasma concentration
decreased
What is the basis for the computation of the loading dose
Volume of distribution
Formula of loading dose
Vd x target plasma conc
After how many half lives does the drug reach a steady state concentration
3-4 half lives
What drug is capable of autoinduction
Carbamazepine
What type of alcoholism is a cyp450 inducer
Chronic alcoholism
What fruit juice is an enzyme inhibitor
Grapefruit juice
How does zero order kinetics appear on semilog paper
Nonlinear
Is the drug elimination in first order kinetics dependent on drug concentration
Yes. Constant fraction eliminated every time
Formula of drug clearance
Elimination rate/plasma conc
Vd x K
What drug competes in the active tubular secretion of penicillin
Probenecid
What component of the GIT contributes to the enterohepatic recycling of drugs
Microbial flora
What drug undergoes intestinal excretion
Doxycycline
