PK

Question 0

First order shape

Answer 0

Semi log

Question 1

Vd =

Answer 1

Dose/Co

Co is extrapolated from line through C at To

Question 2

Zero order shape

Answer 2

Linear

Question 3

Three zero order drugs

Answer 3

Ethanol, ASA, phenytoin

Question 4

1st order vs 0 order

Answer 4

1st: constant fraction eliminated
0: constant amount eliminated

1st: [plama] increases proportionately with dose
0: [plama] increases disproportionately

1st: steady state reached in 4/5 t1/2 with constant dosing
0: steady state never reached

Question 5

t1/2 required to reach steady state

Answer 5

5

Question 6

1st order

Changing the infusion rate will change the ___ of the steady state, but not the ____ required to reach steady state

Answer 6

Level

Time

Question 7

At the end of the 1st t1/2, the drug will reach ___% of the steady state

Answer 7

50

Question 8

Steady state concentration depends on ___ and _____ of administration

Answer 8

Dose and frequency

Question 9

Cl=

Answer 9

Infusion rate / Css

Or

Dose/ area under curve

Question 10

T1/2=

Answer 10

Cl

Or 0.7/ke

Question 11

Most common sites for PK sampling?

Answer 11

Blood, urine, expired air