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Pharm Exam 4 > Antihelminths > Flashcards

Antihelminths Flashcards

0
Q

Benzamidizole mechanism and resistance

A

Mechanism:

  • inhibits micro tubule polymerization
  • inhibits energy production

Resistance: switch beta tubulin isotope, beta tubulin point mutation

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1
Q

Benzimidazoles (bug and stage)

A
  • Nematodes (but also works for certain Cestodes and trematodes)
  • eggs, larvae, and adults
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2
Q

Ivermectin (bug and stage)

A
  • Nematodes
  • microfiliarie

Specifically indicated for onchocerciasis (combo w/ steroid), and lymph filariasis (combo with benzimidazole)

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3
Q

Ivermectin contraindications

A

Loiasis

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4
Q

Ivermectin SE

A

Mazzoti rxn (use steroids)

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5
Q

Benzimidazole SE

A

GI, bone marrow suppression, HA

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6
Q

Ivermectin mechanism (and resistance)

A

Mechanism:
Activated glutamate-gated Cl- channels, causing flaccid paralysis

Resistance:
P- glycoprotein, mutation in channel

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7
Q

DEC indications (bug and stage)

A
  • Nematodes
  • microfilariae, adults
  • specifically indicated for loiasis and lymph filariasis (combo with benzimidazole)
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8
Q

DEC contraindications

A

Onchocerciasis

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9
Q

DEC SE

A

Mazzoti like rxn

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10
Q

DEC mechanism and resistance

A

Mechanism:
Stimulate host immune response

Resist typically not a problem

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11
Q

Pyrantel indication (bug and stage)

A
  • Nematodes in GI lumen

- larvae, adults

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12
Q

Pyrantel SE

A

GI, HA

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13
Q

Pyrantel mechanism and resistance

A

Mech:

  • stimulate nicotinic receptor
  • increase Ach release (spastic paralysis)

Resist typically not a problem

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14
Q

Praziquantel indications (bug and stage)

A
  • trematodes (schistosomiasis)
  • cestodes
  • immature stages and adults
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15
Q

Praziquantel contraindications

A

Intraocular cysticercocis

Reduce dose for liver dz

16
Q

Praziquantel SE

A

GI, HA

17
Q

Praziquantel mechanism and resistance

A

Mech:
- increase membrane permeability to Ca2+ (spastic paralysis)

Resist:
-rare

18
Q

Benzimidazole CI

A

Pregnant, children <2

Pharm Exam 4 (4 decks)

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