Pituitary Tumours (non-functioning) Flashcards

1
Q

Define Pituitary Tumours (non-functioning)

A

Clinically non-functional adenomas (CNFPAs), a pituitary tumour with no hypersecretion of hormone

Micro-adenoma = <1cm
Macro-adenoma = ≥1cm
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2
Q

Aetiology and risk factors of Pituitary Tumours (non-functioning)

A

Unknown
Monoclonal in origin
Hypothalamic hormones + other local growth factors may promote growth of already transformed cell clones

RF:
MEN-1
Familial isolate pituitary adenomas (FIPA)
Carney complex (CNC)

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3
Q

Symptoms of Pituitary Tumours (non-functioning)

A

Mass effect: vomiting, drowsiness, vision problems
Headaches (SOL: worse in the morning and leaning forward + vomiting)
Visual loss
Seizures

Hypogonadism
Hypothyroidism 
Adrenal insufficiency 
Diabetes insipidus
Prolactin raised -> galactorrhoea
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4
Q

Signs of Pituitary Tumours (non-functioning) on examination

A
Mass effect:
Visual field defects (bitemporal hemianopia)
Cranial nerve neuropathies
Hydrocephalus
CSF rhinorrhoea
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5
Q

Investigations for Pituitary Tumours (non-functioning)

A

Full pituitary evaluation (Bloods)
GH/IGF-1 | prolactin | TFTs | LH/GH/testosterone/oestradiol | ACTH/cortisol

MRI: micro or macro adenoma

Visual field assessment: normal or unilateral/bitemporal field defect

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