Osteomalacia Flashcards
Define Osteomalacia
Metabolic bone disease characterise by incomplete mineralisation of the underlying mature bone matrix (osteoid) following growth plate closure in adults
Define Rickets
Metabolic bone disease characterised by defective mineralisation of the epiphyseal growth plate cartilage in children, resulting in skeletal deformities and growth retardation
Aetiology of Osteomalacia
Vitamin D deficiency (sub-optimal UV-B sunlight exposure | sunscreen use | insufficient dietary supplementation | inability of the SI to absorb dietary sources (gastrectomy, coeliac, bariatric weight loss))
Acquired:
Nutritional deficiency (vit D, phosphorus, calcium)
Drug (anticonvulsants)
Liver disease
Chronic kidney disease, hypoparathyroidsim
Renal osteodystophy /CKD-MBD)
Mineralisation inhibitors (bisphosphonates, fluoride)
Tumour induced
Inherited:
Rickets
Hypophosphataemia
Mixed:
Fanconi’s syndrome
Renal tubular acidosis
Symptoms of Rickets and Osteomalacia
Rickets:
Growth retardation
Short stature.
Costochondral junction swelling
Osteomalacia:
Bone pain (diffuse, usually localised to lower extremities, lower spine, ribs, pelvis)
Malaise
Hx of fractures
Signs of Rickets and Osteomalacia
Rickets:
Softening of bone -> deformities (bowed legs, knock knees)
Bossing of frontal and parietal bones
Hypotonia
Costochondral junction swelling (rickets)
Osteomalacia:
Proximal myopathy
Waddling gait
Hypocalcaemia (Trousseau’s, Chvostek’s)
Investigations for osteomalacia
Serum calcium: normal (secondary hyperPTH) or low
Serum 25-hydroxyvitamin D: low <25
Serum phosphate: low
U+Es: Urea and creatinine ratio elevated
Intact PTH: raised
Serum alk phos: Raised
24h urinary calcium and phosphate: low calcium, high phosphate
Bone X-rays:
Subperiosteal region resorption at the phalanges
Bone cysts
Resorption of the distal end of long bones
Reduced bone density and cortex thinning
Osteopenia
Coarse trabeculae
Codfish vertebrae
Looser pseudofractures
CKD-MBD: osteosclerosis
DXA: low bone density
Iliac
Iliac crest biopsy: reduced distance between tetracycline bands
Management for vitamin D deficiency
- Calcium and vit D supplements (ergocalciferol PO, calcium carbonate PO)
- Calcium + vit D metabolite (calcitriol PO + calcium carbonate PO)
Increase dose of vit D if on anticonvulsants, glucocorticoids
Renal failure -> alfacalcidol
Management for inherited or acquired disorders of phosphate wasting/oncogenic osteomalacia
Calcium + vitamin D metabolite + phosphate
Calcitriol (PO)
Sodium phosphate/potassium phosphate (PO)
Calcium carbonate (PO)
Complications of Osteomalacia
Insufficiency fractures or pseudofractures
Secondary hyperparathyroidism
Metastatic calcification in renal failure
Hypercalcaemia
Hypercalciuria and kidney stones