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DEMS Unit 3 > Pituitary Pharmacology > Flashcards

Pituitary Pharmacology Flashcards

1
Q

Somatropin

A

Native growth hormone AA sequence

Indicated for children with GH deficiency; administered daily at bedtime SC or 3x/week IM

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2
Q

Pegvisomant

A

GH receptor antagonist

Role in treatment of acromegaly / gigantism

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3
Q

Mecasermin

A

Recombinant IGF-1

Indicated for treatment of growth hormone insensitivity due to GH receptor mutation (Laron Dwarfism)

Concern for hypoglycemia

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4
Q

Somatostatin analogs - Agents & Uses

A

Octreotide
Lanreotide

Used to treat excess GH (acromegaly in adults, gigantism in children)

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5
Q

Cabergoline

A

Selective D2 agonist; better tolerated than bromocriptine and therefore preferred agent for hyperprolactinemia

Used as adjunctive treatment in management of acromegaly / gigantism

Side effects: Hypotension, dizziness

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6
Q

Bromocriptine

A

Dopamine agonist at D1 receptors

Use in hyperprolactinemia

Side effects: Nausea/vomiting, headache, postural hypotension

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7
Q

DDAVP (Desmopressin)

A

ADH analog; preferred treatment in central diabetes insipidus

Administered IV, IM, Intranasal

Renal action (water retention) mediated via V2 receptors

Vasoconstriction mediated via V1 receptors; occur onl at higher concentrations than those that produce renal effects

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8
Q

Indications for GH replacement

A

GH deficiency - children and adults

Poor growth due to Turner’s Syndrome, Prader-Willi, and chronic renal insufficiency

Wasting or cachexia in AIDS patients

Patients with short bowel syndrome dependent on total parenteral nutrition

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9
Q

Growth Hormone - Side Effects

A

Insulin resistance / glucose intolerance
Idiopathic intracranial hypertension (pseudotumor cerebri)

With misuse in athletes: Acromegaly, arthropathy, visceromegaly

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10
Q

Chlorpropramide

A

1st generation sulfonylurea

Potentiates action of small or residual amounts of ADH

Use for treatment of central diabetes insipidus in patients intolerant to desmopressin

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11
Q

Hydrochlorothiazide

A

Used in treatment of nephrogenic diabetes insipidus

Paradoxically reduces polyuria

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12
Q

Indomethacin

A

Used in treatment of nephrogenic diabetes insipidus

Prostaglandins attenuate ADH-induced anti-diuresis; inhibition of PG synthesis relates to antidiuretic response

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13
Q

ADH-V2 Receptor Antagonists

A

Tolvaptan

Conivaptan

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14
Q

Drugs that can induce diabetes insipidus?

A

Lithium

Demeclocycline

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15
Q

Drugs that can induce SIADH?

A

SSRIs
Haloperidol
TCADs

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16
Q

Somatostatin analogs - Adverse Effects

A

Transient hyperglycemia with subsequent improvement
Abdominal cramps, loose stools
Sinus bradycardia, conduction arrhythmias

DEMS Unit 3 (7 decks)

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