Pituitary Gland Flashcards
Where does the pituitary gland located?
Sella turcica or Turkish saddle (small cavity in the sphenoid bone of the skull)
Pituitary gland and hypothalamus is connected by
Infundibular stalk
True or False: All pituitary hormones have circadian rhythm
True
Pituitqry gland is also known as
Hypophysis
What are the region of the hypophysis
Adenohypophysis and Neurohypophysis
It is the true endocrine gland
Anterior pituitary (adenohypophysis)
It is the true endocrine gland
Anterior pituitary (adenohypophysis)
What hormones does the adenohypophysis regulate and produce
FSH, LH, ACTH, GH, TSH, Prolactin (FLAGToP)
Types of Cells in the Adenohypophysis by Immunochemical test
Somatotrophs - GH
Lactotrophs - Prolactin
Tyrotrophs - TSH
Gonadotrophs - LH and FSH
Corticotrophs - POMC (proopiomelanocortin)
It is the most abundant of all pituitary hormones
GH
GH is controlled by
GH-RH and Somatostatin
Anabolic and metabolic actions of GH are facilitated by
Somatomedin C
The structure of GH is similar to
Prolactin and human placental lactogen
The metabolic effect of GH
Metabolize fat stores while conserving glucose
Major stimulus of GH
Deep sleep (markedly increase GH)
Major inhibitor of GH
Somatostatin
Physiologic stimuli of GH (increased GH)
Stress, fasting, high-protein diet
Pharmacologic stimuli of GH (increased GH)
Sex steroids, apomorphine, and levodopa
GH suppressors
Glococorticoids and elevated fatty acid
Significant in increased GH (disorders)
Acromegaly, chronic malnutrition, renal disease, cirrhosis, sepsis, DM
Significant in decreased GH (disorders)
GHD, obesity, hypothyroidism
Common method for GH
Chemiluminescent Immunoassay
Reference value of GH (fasting)
<10 ng/mL
it is the most commn cause of of GH deficiency in childrenq
Idiopathoc GH
