Pituitary Drugs Flashcards
Octreotide
Functional Classification
Growth Hormone, antidiarrheal
Octreotide
Mechanism of Action
A potent growth hormone similar to somatostatin
Ocreotide
Uses
Sandostatin: acromegaly, improves symptoms of carcinoid tumors, vasoactive intestinal peptide tumors (VIPomas)
LAR Depot: long-term maintenance of acromegaly, carcinoid tumors, VIPomas
Octreotide
Contraindications
Hypersensitivity
Octreotide
Side Effects
CNS: Headache, Dizziness, Fatigue, Weakness, depression, anxiety, tremors, SEIZURE, paranoia
CV: Sinus Bradycardia, Conduction Abnormalities, DYSRHYTHMIAS. chest pain, SOB, thrombophlebitis, ischemia, CHF, hypertension, palpitations, QT PROLONGATION, ST- OR T-WAVE CHANGES
ENDO: Hypo/Hyperglycemia, Ketosis, Hypothyroidism, galactorrhea, diabetes insipidus
GI: Diarrhea, Nausea, Abdominal Pain, Vomiting, Flatulence, Distention, Constipation, HEPATITIS, increased LFTs, GI BLEEDING, PANCREATITIS, cholelithiasis, ileus
GU: UTI
HEMA: hematoma of inj site, bruise
INTEG: rash, urticaria, pain; inflammation at inj site
MS: Joint and Muscle Pain
Octreotide
Nursing Considerations
ASSESS:
- Growth hormone antibodies, IGF-1 at 1- to 4-hr intervals for 8-12 hr after dose (ACROMEGALY); 5-HIAA, plasma serotonin; blood glucose, serotonin levels (CARCINOID TUMORS), plasma substance P, plasma vasoactive intestinal peptide (VIP) (VIPoma)
- Thyroid function tests: T3, T4, T7, TSH to identify hypothyroidism
- Fecal fat, serum carotene
- ALLERGIC REACTION: rash, itching, fever, nausea, wheezing
- CARDIAC STATUS: bradycardia, conduction abnormalities, dysrhythmias; monitor ECG for QT prolongation, low voltage, axis shifts, early repolarization, R/S transition, early wave progression
Somatropin
Functional Classification
Pituitary hormone
Somatropin
Chemical Classification
Growth Hormone
Somatropin
Mechanism of Action
Stimulates growth; somatropin is similar to natural growth hormone; both preparations were developed with the use of recombinant DNA
Somatropin
Uses
Pituitary growth hormone deficiency (hypopituitary dwarfism), children with human growth hormone deficiency/growth failure, AIDS wasting syndrome, cachexia, adults with somatropin deficiency syndrome (SDS), short stature in Noonan syndrome, SHOX deficiency, Turner’s syndrome, Prader-Willi syndrome
Somatropin
Contraindications
Hypersensitivity to benzyl alcohol, creosol; closed epiphyses, intracranial lesions, acute respiratory failure, Prader-Willi syndrome with obesity, trauma
Somatropin
Side Effects
CNS: headache, growth of intracranial tumor, fever, aggressive behavior
ENDO: hyperglycemia, ketosis, hypothyroidism
GI: nausea, vomiting
GU: Hypercalciuria
INTEG: rash, urticaria, pain; inflammation at inj site, hematoma
MS: tissue swelling, joint and muscle pain
SYST: ANTIBODIES TO GROWTH HORMONE
Somatropin
Nursing Considerations
- Signs/symptoms of diabetes
- Growth hormone antibodies if patient fails to respond to therapy
- Thyroid function tests: T3,T4,T7, TSH to identify hypothyroidism
- ALLERGIC REACTION: rash, itching, fever, nausea, wheezing
- HYPERCALCIURIA: urinary stones; groin, flank pain; nausea, vomiting, urinary frequency, hematuria, chills
- Growth rate, bone age of child at intervals during treatment
Vasopressin
functional Classification
pituitary hormone
Vasopressin
Chemical Classification
Lysine, Vasopressin
Vasopressin
Mechanism of Action
Promotes the reabsorption of water via action on the renal tubular epithelium; causes vasoconstriction
Vasopressin
Uses
Diabetes insipidus (nonnephrogenic/nonpsychogenic), abdominal distention postoperatively, bleeding esophageal varices
Vasopressin
Contraindications
Hypersensitivity, chronic nephritis
Vasopressin
Side Effects
CNS: drowsiness, headache, lethargy, flushing, vertigo
CV: increased BP, dysrhythmias, CARDIAC ARREST, SHOCK, chest pain, MI
EENT: nasal irritation, congestion, rhinitis
GI: nausea, heartburn, cramps, vomiting, flatus
GU: vulval pain, uterine cramping
MISC: tremor, sweating, vertigo, urticaria, bronchial constriction
Vasopressin
Nursing Considerations
ASSESS:
- Pulse, BP when giving product IV or IM
- I& ratio, weight daily; fluid/electrolyte balance; check for edema in extremities; if water retention is severe, diuretic may be prescribed
- WATER INTOXICATION: lethargy, behavior changes, disorientation, neuromuscular excitability
- Small doses may precipitate coronary adverse effects; keep emergency equipment nearby
Octreotide
Chemical Classification
Synthetic Octapeptide