Pituitary

Question 1

Effects of GH

Answer 1

Promotes membranous ossification ( skull and mandible )

Stimulates chondrogenesis

Stimulates growth of soft tissue and viscera

Direct
Na retention
Reduce insulin sensitivity

Question 2

Types of hormones secreted by pituitary

Answer 2

FSH, LH
TSH
Are glycoproteins

Rest are polypeptides

Question 3

Types of cells that secrete different hormones from the pituitary

Answer 3

Somatotrophes(GH) , lactotrophes ( prolactin ) are acidophilic

Corticotrophes, thyrotrophes, gonadotrophes are basophilic

Question 4

GH t1/2

Answer 4

6-20 min

Question 5

What percentage of GH are in the bound form

Answer 5

50%

Question 6

GH - receptor action , describe

Answer 6

The growth hormone has 2 receptors , when one binds to a GH receptor , the second site attracts another receptor.
This dimerization is required for the receptor activation.

GH -> JAK2( cytoplasmic tyrosine kinase ) -> that phosphorylates STAT_> does the task

Question 7

JAK stat pathway

Answer 7

Prolactin GH and various other growth factors follow the same pathway

Question 8

Somatomedins

Answer 8

IGF -1 stimulates somatostatin secretion

IGF-2( plays a role in the fetus )

Closely related to insulin

Thyroxin stimulates the action

POPYPEPTIDES

Insulin like activity
Anti lipolytic activity
Protein synthesis
Epiphyseal growth

Question 9

Ghrelin

Answer 9

Hunger hormone

Secretes when hungry