Adrenal

Question 1

Hypertension in cushings

Answer 1

1. Glucocorticoids have high affinity for mineralocaoticoid receptors
   But in cushings 11BHD 2 saturated
2. Glucocorticoids have a permissive action on catecholamines
3. Gluco stimulate PNMT release to convert noradrenaline to adrenaline
4. Increase the formation of deoxyxorticosterone
5. Increase formation of angiontensinigon and direct effect on blood vessels

Question 2

Factors that cause an increase in aldosterone secretion

Answer 2

Hemorrhage ( volume depletion ) 
Increased plasma K
Low plasma Na 
Construction of IVC in thorax 
Standing 
Ang ii 
ACTH

Question 3

Factors that increase ADH secretion

Answer 3

Volume depletion
Standing
Ang ii
Pain exercise

ALCOHOL - decrease ADH secretion

Question 4

What is the adrenal medulla

Answer 4

Sympathetic ganglion when the post ganglionic neurons have lost their axons and become secretory cells

Question 5

Excretion Of catecholamines

Answer 5

50% meta nephrine and normetanephrine

35% VMA

small amount free adrenaline and noradrenaline

Question 6

Actions of cortisol

Answer 6

Metabolic
1. Carb ( liver , muscle , adipose tissue )2. Protein 3. Fat 4. Hormones 5. Water

Bones
Immune
Growth 
GI
Skin

BINGOS

Nerves