Pituitary 3 Flashcards
5 physiologic functions of PRL (prolactin)
- Milk production
- Steroidogensis in adrenals
- Metabolism of fats/carbs
- Vit D metabolism
- Fetal development
2 main functions of PRL?
- Mammary gland development (puberty)
- Initiation of lactation post-partum (pregnancy)
PRL is secreted by what?
Where are they secreted?
What is the manner?
- Lactotrophs
- Anterior pituitary
- Pulsatile
PRL is inhibited by what??
Prolactin Inhibitory Factor
(Dopamine)
PRL is stimulated by what??
High Thyrotropin Releasing Hormone
PRL is increased by what 2 things?
Smaller increases occur w/ what 6 things?
- CW motion & nipple stimulation
- After sleep
- Exercise
- Intercourse
- Stress
- Pregnancy
- Lactation
PRL suppresses which 3 hormones?
Suppression of this hormone leads to what sxs?
- Gonadotropin Releasing Hormone (GnRH)
- LH and FSH are lowered too as result
- –> altered menses & fertility
PRL stimulates adrenal androgen production leading to what 2 sxs?
- Weight gain
- Hirsuitism (esp women)
What are 4 S/S of Hyperprolactinemia in ONLY women?
◦Irregular menstruation
◦Menopausal symptoms
◦Weight gain
◦Signs of increased androgens (hirsuitism)
What are 2 S/S of Hyperprolactinemia in ONLY men?
◦Impotence
◦Gynecomastia
What are S/S of Hyperprolactinemia in BOTH men/women?
- Infertility
- HA
- Loss of libido
- Peripheral Vision Problems
- Moods changes/ depression
- Galactorrhea
What 2 sxs are indicative of MACROadenoma when PRL levels are elevated?
- HA & Vision Changes
Fasting Serum Prolactin Levels should be measured in ALL pts w/ what 3 sxs?
- galactorrhea
- gynecomastia
- hypogonadism
What does “further work up” for Hyperprolactinemia entail?
MRI (with or without contrast)
What are some causes of Hyperprolactinemia?
}Prolactinoma (autonomous production)
}Other pituitary tumors (GH, ACTH)
}Hypothalamic disease
}Chronic Kidney Failure (decreased clearance by kidneys)
}Cirrhosis or Liver Disease
}Spinal cord damage
}Chest wall injury (such as in herpes zoster or surgery)
}Severe Primary Hypothyroidism (high TRH)
}Anti-psychotic medications
}Radiation, Surgery
}Idiopathic
1st and 2nd MC cause of Pituitary Adenomas?
Least common?
- PRL (40-45%)
- GH (20%)
LC: TSH (1-2%)
What type of PRL level if above 200 is HIGHY suggestive of a PRL secreting adenoma?
Basal (fasting serum) PRL level