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Biotechnology > Pierce: Cancer Biotech > Flashcards

Pierce: Cancer Biotech Flashcards

1
Q

chemical found in China’s baby milk formula

A

melamine

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2
Q

popular blood thinner used in surgery and dialysis

A

heparin

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3
Q

heparin drug scare cause by this country

A

china

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4
Q

estimate number of deaths from cancer for men (same as for women)

A

~300,000 (less in women)

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5
Q

cancer type causes greatest number of deaths

A

lung/bronchus

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6
Q

cancer death rates over the past decades (trend)

A

decreasing (more for men-although still higher)

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7
Q

only type of cancer that has increased since 1930

A

lung/bronchus

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8
Q

type of cancer has decreased the most (in US) since 1930

A

stomach

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9
Q

race/ethnicity with highest rates of cancer

A

african american (esp. men)

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10
Q

estimated most common cancer type in men for 2013

A

prostate

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11
Q

estimated most common cancer type in women for 2013

A

breast

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12
Q

estimate of new cancer cases for men in 2013 (or for women)

A

~850,000 (slightly less in women)

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13
Q

cancer type increase in reported cancer incidences for men

A

prostate

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14
Q

cancer incidence rates highest for (race/sex)

A

african american men

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15
Q

cancer incidence rates lowest for (race/sex)

A

african american women

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16
Q

lifetime probability of developing cancer for women

A

1 in 3

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17
Q

lifetime probability of developing cancer for men

A

1 in 2

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18
Q

% prevelance of obesity

A

about 35%

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19
Q

number of states with “overweight” prevelance greater than 55%

A

all 50 states

20
Q

name for a non-invasive tumor

A

benign tumor

21
Q

accumulation of mutations from a benign tumor leads to this type of carcinoma

A

in situ carcinoma

22
Q

carcinoma in situ progresses to this type of carcinoma

A

invasive carcinoma

23
Q

another term for invasive carcinoma

A

malignant carcinoma

24
Q

term for invasion of blood/lymph vessels by carcinoma

A

metastatic

25
Q

cells that are growing rapidly lose their ability to:

A

keep other mutations from occuring

26
Q

mutations occur in genes that keep cells from:

A

invading surrounding tissues

27
Q

invasive cancer is:

A

malignant

28
Q

change from malignant to metastatic is due partly to altered:

A

adhesive behaviors of cells

29
Q

cancer cells have increases in these two things on cell surface

A

neu/her-2 receptors, oligosaccharide branching

30
Q

new evidence suggests that some cancers derived from:

A

stem cell populations

31
Q

4 types of cancers associated with stem cells

A

leukemia, myeloma, glioma, breast carcinoma

32
Q

cell type with possible over expression of Her-2/neu

A

mammary epithelial cells

33
Q

receptor types typically upregulated in cancer cells

A

growth factor

34
Q

cancer type shows upregulation of Estrogen receptor:

A

breast/ovarian

35
Q

cancer type shows upregulation of Testosterone receptor:

A

prostate

36
Q

cancer type shows upregulation of Her-2 receptor

A

breast/prostate

37
Q

cancer type shows upregulation of PDGF receptor

A

lung/prostate/soft tissue

38
Q

Estrogen receptor antagonists for Tx of breast cancer

A

Tamoxifen

39
Q

chronic myelogenous leukemia caused by upregulation of: due to reciprocol translocation (downstream of bcr)

A

abl oncogene

40
Q

drug used to target abl oncogene and treat chronic myelogenous leukemia

A

GLEEVEC

41
Q

chronic myelogenous leukemia (CML) second generation kinase inhibitor:

A

omacetaxine

42
Q

CML compination inhibitor

A

Ponatinib

43
Q

herceptin, rituxan, erbitux, and zevalin are all examples of:

A

cytotoxic monoclonal antibodies

44
Q

cost of Gleevec per month

A

$2500/month

45
Q

cost of Folotyn per month

A

$30,000/month

46
Q

costly TNF-alpha inhibitor

A

Enbrel

Biotechnology (2 decks)

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