Pierce: Cancer Biotech

Question 1

chemical found in China’s baby milk formula

Answer 1

melamine

Question 2

popular blood thinner used in surgery and dialysis

Answer 2

heparin

Question 3

heparin drug scare cause by this country

Answer 3

china

Question 4

estimate number of deaths from cancer for men (same as for women)

Answer 4

~300,000 (less in women)

Question 5

cancer type causes greatest number of deaths

Answer 5

lung/bronchus

Question 6

cancer death rates over the past decades (trend)

Answer 6

decreasing (more for men-although still higher)

Question 7

only type of cancer that has increased since 1930

Answer 7

lung/bronchus

Question 8

type of cancer has decreased the most (in US) since 1930

Answer 8

stomach

Question 9

race/ethnicity with highest rates of cancer

Answer 9

african american (esp. men)

Question 10

estimated most common cancer type in men for 2013

Answer 10

prostate

Question 11

estimated most common cancer type in women for 2013

Answer 11

breast

Question 12

estimate of new cancer cases for men in 2013 (or for women)

Answer 12

~850,000 (slightly less in women)

Question 13

cancer type increase in reported cancer incidences for men

Answer 13

prostate

Question 14

cancer incidence rates highest for (race/sex)

Answer 14

african american men

Question 15

cancer incidence rates lowest for (race/sex)

Answer 15

african american women

Question 16

lifetime probability of developing cancer for women

Answer 16

1 in 3

Question 17

lifetime probability of developing cancer for men

Answer 17

1 in 2

Question 18

% prevelance of obesity

Answer 18

about 35%

Question 19

number of states with “overweight” prevelance greater than 55%

Answer 19

all 50 states

Question 20

name for a non-invasive tumor

Answer 20

benign tumor

Question 21

accumulation of mutations from a benign tumor leads to this type of carcinoma

Answer 21

in situ carcinoma

Question 22

carcinoma in situ progresses to this type of carcinoma

Answer 22

invasive carcinoma

Question 23

another term for invasive carcinoma

Answer 23

malignant carcinoma

Question 24

term for invasion of blood/lymph vessels by carcinoma

Answer 24

metastatic

Question 25

cells that are growing rapidly lose their ability to:

Answer 25

keep other mutations from occuring

Question 26

mutations occur in genes that keep cells from:

Answer 26

invading surrounding tissues

Question 27

invasive cancer is:

Answer 27

malignant

Question 28

change from malignant to metastatic is due partly to altered:

Answer 28

adhesive behaviors of cells

Question 29

cancer cells have increases in these two things on cell surface

Answer 29

neu/her-2 receptors, oligosaccharide branching

Question 30

new evidence suggests that some cancers derived from:

Answer 30

stem cell populations

Question 31

4 types of cancers associated with stem cells

Answer 31

leukemia, myeloma, glioma, breast carcinoma

Question 32

cell type with possible over expression of Her-2/neu

Answer 32

mammary epithelial cells

Question 33

receptor types typically upregulated in cancer cells

Answer 33

growth factor

Question 34

cancer type shows upregulation of Estrogen receptor:

Answer 34

breast/ovarian

Question 35

cancer type shows upregulation of Testosterone receptor:

Answer 35

prostate

Question 36

cancer type shows upregulation of Her-2 receptor

Answer 36

breast/prostate

Question 37

cancer type shows upregulation of PDGF receptor

Answer 37

lung/prostate/soft tissue

Question 38

Estrogen receptor antagonists for Tx of breast cancer

Answer 38

Tamoxifen

Question 39

chronic myelogenous leukemia caused by upregulation of: due to reciprocol translocation (downstream of bcr)

Answer 39

abl oncogene

Question 40

drug used to target abl oncogene and treat chronic myelogenous leukemia

Answer 40

GLEEVEC

Question 41

chronic myelogenous leukemia (CML) second generation kinase inhibitor:

Answer 41

omacetaxine

Question 42

CML compination inhibitor

Answer 42

Ponatinib

Question 43

herceptin, rituxan, erbitux, and zevalin are all examples of:

Answer 43

cytotoxic monoclonal antibodies

Question 44

cost of Gleevec per month

Answer 44

$2500/month

Question 45

cost of Folotyn per month

Answer 45

$30,000/month

Question 46

costly TNF-alpha inhibitor

Answer 46

Enbrel