Pictures!

Question 1

Answer 1

Mast cell activation in hypersensitivity I- bovine anaphylaxis

Question 2

Answer 2

Granule granulomas Hypersensitivity III

Question 3

Answer 3

Multi-focal morphology

Question 4

Answer 4

Hemorrhagic exudate from profound tissue damage and vascular permeability

Acute, diffuse hemorrhagic enteritis from Lawsonia

Question 5

Answer 5

Granulation tissue zone- necrotic debris and fibrin

Circled: macrophage

Question 6

Answer 6

Granulomatous inflammation-

epitheliod macrophages and multinucleated giant cells

Question 7

Answer 7

Fibrinoid necrosis

Question 8

Answer 8

Chronic fibrinopurulent pericarditis and granulation tissue

Question 9

Answer 9

Fibrinopurulent - fibrin and neutrophils

Puppy with perforating roundworm infection

Sheets of fibrin forming on hepatic surface, neutrophils and blood leaking from vessels

Red, inflamed hyperemic intestines

Acute, diffuse fibrinopurulent peritonitis

Question 10

Answer 10

Coccidioides immitis spherule

Question 11

Answer 11

Hemorrhagic exudate from hemorrhagic enteritis

Common in Parvovirus

Question 12

Answer 12

Simple granuloma- compact and organized exudate collection

Question 13

Answer 13

Fibrinous pleuritis with fibrous adhesions (blue arrow)

Question 14

Answer 14

Chronic immune complex glomerulonephritis

Question 15

Answer 15

Focal

Question 16

Answer 16

Necrotic exudate

Multifocal necrotizing abomasitis

Change in abomasal acidity allowing fungal growth - Fungal hyphae cause necrosis and hemorrhage

Question 17

Answer 17

Fibrinous exudate

ABundant fibrin, hyperemic vessels

Question 18

Answer 18

Fibrinous exudate

Question 19

Answer 19

Epithelioid cells from macrophages

(called such because they form sheets that look like epithelium)

Question 20

Answer 20

Suppurative (purulent) exudate of rabbit uterus

Neutrophil dominated

Bacteria- pasturella multocida infection

Question 21

Answer 21

Shigella gingivitis - inflammatory reaction - swelling, heat

Question 22

Answer 22

Schizogany occuring- leads to proliferative response of mucosa

Question 23

Answer 23

Complex granuloma- Have central areas of necrosis or calcification

Question 24

Answer 24

Granule granulomas Hypersensitivity III

Question 25

Answer 25

Fibrinoid necrosis

Question 26

Answer 26

Coccidioides immitis endospores

Question 27

Answer 27

Lymphocytic exudate Chronic Lymphocytic Abomasitis Cow abomasum with Ostertagia infection- parasites invade mucoase Chronic vascular permeability leads to protein losing enteropathy

Question 28

Answer 28

Hyperplastic inflammation Chronic multifocal hyperplastic enteritis Hyperplasia as a dominant feature of the exudate Sheep SI with coccidial infection of eimeria, schizogany in mucosa causes proliferation and induces

Question 29

Answer 29

Multiple expansile simple granulomas Inflammatory response of multinucleated cells and epitheliod cells creating 3D expansive lesions that resemble tumors

Question 30

Answer 30

Fibrosis scarring in airways

Question 31

Answer 31

Fibrinous exudate Acute locally extensive fibrinous pleuritis

Question 32

Answer 32

Regeneration of esophagus epithelium in BVD virus

Question 33

Answer 33

Ingrowing capillaries in granulation tissue, macrophages

Question 34

Answer 34

Granule granuloma from hypersensitivity III Immune complex

Question 35

Answer 35

Diffuse

Question 36

Answer 36

Chonic diffuse granulomatous enteritis andlympadenitis Johne's disease - chronic granulomatous enteritis Lymph node with off-white infiltrate from viable macrophages causing space occupying lesions

Question 37

Answer 37

Necrotic exudate Necrotizing and hemorrhagic lesions Inflammation associated with fungal infection

Question 38

Answer 38

Fibrinonecrotic exudate- classic in salmonella in cattle Acute diffuse fibrinonecrotic enteritis

Question 39

Answer 39

Locally extensive

Question 40

Answer 40

Suppurative exudate leading to: Abscess- Organized focal collection of neutrophils Rabbit brain- focal chronic suppurative encephalitis from pasturellosis

Question 41

Answer 41

Chronic multifocal ulcerative colitis Tissue proliferation around edges from epithelial hyperplasia and fibrosis Feline colon with chronic leukemia and fungal infection due to immunosupression

Question 42

Answer 42

Repair and fibrosis

Question 43

Answer 43

Fibrinopurulent exudate (fibrin accumulation on surfaces and purulent exudate) Chronic diffuse fibrinopurulent pericarditis Pericardial sac of Hardware disease cow

Question 44

Answer 44

Granulomatous inflammation ## Footnote Macrophages break down villi and replace with exudate dominated by macrophages

Question 45

Answer 45

Suppurative exudate - "sad looking nuclei", occasional intact neutrophil, but once they arrive, undergo apoptosis or necrosis Create tissue destruction

Question 46

Answer 46

Multinucleated giant cells

Question 47

Answer 47

Necrotic exudate Local extensive necrotizing (or necrotizing and hemorrhagic) Gas bubbles from clostridium (also some coagulation necrosis and hemorrhage)

Question 48

Answer 48

Eosinophilic inflammatory reaction Usually greenish coloration of tissue, but microscopically will show eosinophils (associated with parasitic infections, helper T cell response from migrating larvae release chemokine agent for eosinophils which kill via Major Basic Protein) Can also be in response to aberrant reactions to allergens

Question 49