Pics 3: anemia/iron Flashcards

1
Q

Hemolysis overview: hereditary vs acquired

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2
Q

DAT and indirect DAT

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3
Q

Ddx DAT positive

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3
Q

Mechanisms of hemolysis
WAIHA
Cold AIHA

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4
Q

WAIHA 1L rx

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4
Q

DDX DAT neg

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5
Q

Cold agglutinin syndromes:
Causes in 3 categories

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5
Q

WAIHA 2L Rx

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5
Q

WAIHA emerging and upcoming therapies and targets

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6
Q

WAIHA 3L/4L

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7
Q

AIHA types review chart

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7
Q

PCH lab features

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8
Q

Cold acting antibody diseases
But 1 isn’t hemolytic
CAD and PCH vs cryoglobulinemia

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8
Q

Mechanisms of DI AIHA
3 mechanisms

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9
Q

PNH symptoms/signs
Body diagram

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10
Q

Eculizumab diagram, MOA

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11
Q

Summary diagram of compliment inhibitors, including new ones

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12
Q

PNH summary slide

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13
Q

Anemia approach

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14
Q

Hemolytic anemias
Clinical symptoms/course/complications

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15
Q

B12 and folate absorption

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16
Q

Various classification schemas of hemolytic anemias

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17
Q

High yield teaching points: Anemia summary slide
HS
HE
G6PD
PK
megaloblastic
pernicious anemia
Copper def

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17
Q

Complications of chronic hemolysis: pathophys picture

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18
Q

RBC cytoskeleton and groups of membranopathies

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19
Q

G6PD drugs

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19
Q

Membraneopathy genetics
HS
HE/HPP

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20
Q

Ddx DAT patterns

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20
Q

Chart: immune injury to RBCs by type:
Warm Ab
Cold Ab
Mixed Ab
Drug induced hemolysis

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21
Q

Mechanisms of drug induced hemolytic anemias:
3 prototypical types
plus protein adsorption affecting DAT

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22
Q

Complement cascade with inhibitors

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23
Q

DDX fragmentation hemolysis

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24
Q

Factors changing dietary iron absorption

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24
Q

Underproduction anemias by MCV
Plus “other” category

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25
Q

Causes of IDA

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26
Q

Lab findings related to iron:
normal, iron depletion, iron restricted erythropoiesis, IDA

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27
Q

Iron studies/Labs
IDA vs AOCD

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28
Q

Causes B12 def

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29
Q

Causes folate def

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30
Q

Supportive care for acute porphyria

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30
Q

Anemia in Older adults
Approach

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30
Q

Classification of PRCA
Congenital vs acquired
Different secondary causes

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31
Q

Algorithm for diagnosis of acute porphyrias
Which are treated with Hemin?
Order of lab testing?

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32
Q

Acute porphyrias table
4 types

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33
Q

Blistering cutaneous porphyria table
3 types

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33
Q

Nonblistering cutaneous porphyria table
2 types

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34
Q

Heme synthesis pathway
Start where?
Mitochrondial and cytosolic steps?

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35
Q

Iron overload
Assessment of overload status and monitoring for A/Es of chelators

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36
Q

Chelator agents table

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37
Q

Hemochromatosis natural history
Effects over lifetime

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38
Q

Consequences of free iron, oxidative stress and response to oxidative stress

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39
Q

HFE genotypes
Common?
Which can cause HH?

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40
Q

Hepcidin regulation
By transferrin binding

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41
Q

Iron balance regulation
Hepcidin and the liver

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42
Q

Intestinal iron absorption
Picture with channels etc

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43
Q

Chelation: adverse effects

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44
Q

Body iron homeostasis

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45
Q

IV iron preparations
Indications
Test dose needed/black box warning?

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46
Q

Iron high yield teaching points:
PO iron
IV iron
Hepcidin
IRIDA
Anemia of inflam
HH
Deferiprone
Sideroblastic anemia

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47
Q

Iron movement in body: simplified diagram

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48
Q

Diet iron and absorption
Modifiers of absorption

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49
Q

Hepatocyte and hepcidin regulation of iron

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50
Q

Iron mediated regulation of hepcidin

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51
Q

Inflammation regulation of hepcidin

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52
Q

Erythroferrone and hepcidin

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53
Q

Hepatocyte: systemic iron regulation
By hepcidin
By ferroportin

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54
Q

Iron restricted erythropoiesis picture

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55
Q

Manifestations of iron overload

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56
Q

HFE hemochromatosis summary slide

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56
Q

Hepcidin -> ferroportin -> iron metabolism
Summary of IDA, AOCD, HH, Iron loading anemia

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