Pics 3: anemia/iron Flashcards by Victoria DeVito

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Hemolysis overview: hereditary vs acquired

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DAT and indirect DAT

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Ddx DAT positive

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Mechanisms of hemolysis
WAIHA
Cold AIHA

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WAIHA 1L rx

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DDX DAT neg

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Cold agglutinin syndromes:
Causes in 3 categories

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WAIHA 2L Rx

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WAIHA emerging and upcoming therapies and targets

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WAIHA 3L/4L

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AIHA types review chart

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PCH lab features

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Cold acting antibody diseases
But 1 isn’t hemolytic
CAD and PCH vs cryoglobulinemia

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Mechanisms of DI AIHA
3 mechanisms

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PNH symptoms/signs
Body diagram

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Eculizumab diagram, MOA

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Summary diagram of compliment inhibitors, including new ones

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PNH summary slide

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Anemia approach

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Hemolytic anemias
Clinical symptoms/course/complications

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B12 and folate absorption

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Various classification schemas of hemolytic anemias

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High yield teaching points: Anemia summary slide
HS
HE
G6PD
PK
megaloblastic
pernicious anemia
Copper def

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Complications of chronic hemolysis: pathophys picture

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RBC cytoskeleton and groups of membranopathies

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G6PD drugs

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Membraneopathy genetics
HS
HE/HPP

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Ddx DAT patterns

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Chart: immune injury to RBCs by type:
Warm Ab
Cold Ab
Mixed Ab
Drug induced hemolysis

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Mechanisms of drug induced hemolytic anemias:
3 prototypical types
plus protein adsorption affecting DAT

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Complement cascade with inhibitors

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DDX fragmentation hemolysis

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Factors changing dietary iron absorption

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Underproduction anemias by MCV
Plus “other” category

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Causes of IDA

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Lab findings related to iron:
normal, iron depletion, iron restricted erythropoiesis, IDA

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Iron studies/Labs
IDA vs AOCD

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Causes B12 def

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Causes folate def

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Supportive care for acute porphyria

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Anemia in Older adults
Approach

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Classification of PRCA
Congenital vs acquired
Different secondary causes

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Algorithm for diagnosis of acute porphyrias
Which are treated with Hemin?
Order of lab testing?

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Acute porphyrias table
4 types

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Blistering cutaneous porphyria table
3 types

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Nonblistering cutaneous porphyria table
2 types

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Heme synthesis pathway
Start where?
Mitochrondial and cytosolic steps?

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Iron overload
Assessment of overload status and monitoring for A/Es of chelators

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Chelator agents table

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Hemochromatosis natural history
Effects over lifetime

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Consequences of free iron, oxidative stress and response to oxidative stress

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HFE genotypes
Common?
Which can cause HH?

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Hepcidin regulation
By transferrin binding

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Iron balance regulation
Hepcidin and the liver

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Intestinal iron absorption
Picture with channels etc

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Chelation: adverse effects

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Body iron homeostasis

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IV iron preparations
Indications
Test dose needed/black box warning?

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Iron high yield teaching points:
PO iron
IV iron
Hepcidin
IRIDA
Anemia of inflam
HH
Deferiprone
Sideroblastic anemia

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Iron movement in body: simplified diagram

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Diet iron and absorption
Modifiers of absorption

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Hepatocyte and hepcidin regulation of iron

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Iron mediated regulation of hepcidin

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Inflammation regulation of hepcidin

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Erythroferrone and hepcidin

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Hepatocyte: systemic iron regulation
By hepcidin
By ferroportin

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Iron restricted erythropoiesis picture

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Manifestations of iron overload

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HFE hemochromatosis summary slide

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Hepcidin -> ferroportin -> iron metabolism
Summary of IDA, AOCD, HH, Iron loading anemia

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